苦参碱联合阿德福韦酯治疗乙型病毒性肝炎的效果及对患者血清sST2、CEA及ALT水平的影响  

Clinical efficacy of matrine combined with adefovir dipivoxil tablets in the treatment of viral hepatitis B and its influence on the serum levels of soluble growth stimulating gene 2 protein,carcinoembryonic antigen and alanine transaminase

作　　者：王卫 王媛媛 年娟娟 王旭东 WANG Wei;WANG Yuan-yuan;NIAN Juan-juan;WANG Xu-dong(Department of Drug and Equipment,Shaanxi Aerospace Hospital,Xi'an 710025,Shaanxi,CHINA;Department of Gastroenterology,Shaanxi Aerospace Hospital,Xi'an 710025,Shaanxi,CHINA)

机构地区：[1]陕西航天医院药械科,陕西西安710025 [2]陕西航天医院消化内科,陕西西安710025

出　　处：《海南医学》2023年第11期1548-1551,共4页Hainan Medical Journal

摘　　要：目的观察苦参碱联合阿德福韦酯治疗乙型病毒性肝炎的效果,并探讨其对患者血浆可溶性生长刺激表达基因2蛋白(sST2)、癌胚抗原(CEA)及谷丙转氨酶(ALT)水平的影响。方法选取2019年1月至2021年1月于陕西航天医院就诊的60例乙型病毒性肝炎患者纳入研究,按照随机数表法分为对照组和观察组各30例。对照组患者采用阿德福韦酯治疗,观察组患者采用苦参碱联合阿德福韦酯治疗,疗程3个月。比较两组患者的治疗效果、治疗前后的sST2、CEA、ALT水平、乙肝病毒(HBV)DNA转阴情况和并发症发生情况。结果观察组患者的治疗总有效率为93.33%,明显高于对照组的70.00%,差异具有统计学意义(P<0.05);两组患者治疗后的sST2、CEA和ALT明显低于其治疗前,且观察组患者治疗后的sST2、CEA和ALT水平分别为(0.32±0.03)μg/mL、(0.94±0.02)μg/L、(72.36±10.04)U/L,明显低于对照组的(0.62±0.04)μg/mL、(1.12±0.03)μg/L、(93.57±10.13)U/L,差异均具有统计学意义(P<0.05);观察组治疗后的HBV DNA转阴率为26.67%,明显低于对照组的53.33%,差异具有统计学意义(P<0.05);治疗期间,两组患者的并发症发生率比较差异无统计学意义(P>0.05)。结论苦参碱联合阿德福韦酯治疗乙型病毒性肝炎能有效降低患者的血清sST2、CEA及ALT水平,提高治疗效果。Objective To observe the clinical efficacy of matrine combined with adefovir dipivoxil tablets in the treatment of viral hepatitis B,and to explore its influence on the serum levels of soluble growth stimulating gene 2 protein(sST2),carcinoembryonic antigen(CEA),and alanine transaminase(ALT).Methods Sixty patients with viral hepatitis B in Shaanxi Aerospace Hospital from January 2019 to January 2021 were included in the study.According to random number table,they were divided into a control group and an observation group,with 30 patients in each group.The patients in the control group were given adefovir dipivoxil tablets,while those in the observation group were given matrine combined with adefovir dipivoxil tablets,for 3 months.The clinical efficacy,sST2,CEA,ALT levels before and after treatment,negative conversion of hepatitis B virus(HBV)DNA,and complications were compared between the two groups.Results The overall efficacy rate in the observation group was 93.33%,which was significnatly higher than 70.00%in the control group(P<0.05).The sST 2,CEA,and ALT were significantly lower than before treatment,and the sST2,CEA and ALT levels in the observation group were(0.32±0.03)μg/mL,(0.94±0.02)μg/L,and(72.36±10.04)U/L,which were significantly lower than(0.62±0.04)μg/mL,(1.12±0.03)μg/L,and(93.57±10.13)U/L in the control group(P<0.05).The negative conversion rate of HBV DNA in the observation group was 26.67%,which was sig-nificnatly lower than 53.33%in the control group(P<0.05).During the treatment,there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Matrine combined with adefovir dipiv-oxil tablets in the treatment of viral hepatitis B can effectively reduce the serum levels of sST2,CEA,and ALT in pa-tients,and improve the therapeutic effect.

关 键 词：乙型病毒性肝炎 阿德福韦 苦参碱 可溶性生长刺激表达基因2蛋白 癌胚抗原 谷丙转氨酶 

分 类 号：R512.62[医药卫生—内科学]