鲤疱疹病毒2型不同分离株的基因组比较分析  

Comparative Genome Analysis of Different Isolatess of Cyprinid Herpesvirus 2

作　　者：周怡 赵路品 刘笑茹 姜有声[1,2,3] ZHOU Yi;ZHAO Lupin;LIU Xiaoru;JIANG Yousheng(National Pathogen Collection Center for Aquatic Animals,Shanghai Ocean University,Shanghai 201306,China;Key Laboratory of Agriculture Ministry for Freshwater Aquatic Genetic Resources,Shanghai Ocean University,Shanghai 201306,China;National Experimental Teaching Demonstration Center for Fishery Sciences,Shanghai Ocean University,Shanghai 201306,China)

机构地区：[1]上海海洋大学,国家水生动物病原库,上海201306 [2]上海海洋大学,水产科学国家级实验教学示范中心,上海201306 [3]上海海洋大学,水产动物遗传育种中心上海市协同创新中心,上海201306

出　　处：《水产养殖》2023年第6期20-27,共8页Journal of Aquaculture

基　　金：国家重点研发计划(2019YFD0900101)。

摘　　要：从流行病学和病原学方面简述了鲤疱疹病毒2型(Cyprinid herpesvirus 2,CyHV-2),对感染CyHV-2的金鱼、鲫的状态进行了比较。通过GenBank数据库查找,显示CyHV-2完整基因序列有7株,虽然这7株的基因组具有很高的同源性,但是不同的分离株在其基因组中包含很多突变、插入、缺失和重排。CyHV-2基因组约含150个ORF,其中部分ORF的功能在病毒感染过程中起重要作用。CyHV-2是一种具有高度传染性的病原体,主要感染金鱼、鲫及其变种,严重危害金鱼和异育银鲫养殖业发展。指出,应以CyHV-2的基因组序列为基础,加强对CyHV-2的基因功能以及宿主对CyHV-2的免疫反应等基础研究,以获得更有效地预防、控制和治疗方法,遏制其病毒的传播扩散。The epidemiological and pathogenic aspects of Cyprinid herpesvirus 2(CyHV-2)were briefly described,and the status of goldfish and crucian carp infected with CyHV-2 was compared.At present,7 CyHV-2 complete gene sequences have been published.Although the genomes of 7 strains have high homology,but different isolates contain many mutations,insertions,deletions and rearrangements in their genomes.The CyHV-2 genome contains about 150 ORFs,and the function of these ORFs plays an important role during viral infection.CyHV-2 is a highly contagious pathogen.The virus is known to be highly pathogenic to ornamental goldfish(Carassius auratus)and crucian carp(C.carassius),and also to the hybrids of goldfish and other carps,which resulted in incalculable economic losses in goldfish and Gibel carp(C.auratus gibelio)farming industry.We should strengthen the research on the function of CyHV-2 and provide more effective methods for the prevention and treatemnt of CyHV-2 based on its gene sequence.

关 键 词：鲤疱疹病毒2型 基因组学 蛋白功能 

分 类 号：S917[农业科学—水产科学]