N-(4-溴-2,6-二氯苯基)吡嗪-2-胺的合成与表征  

Synthesis and characterization of N-(4-Bromo-2,6-dichlorophenyl)pyrazin-2-amine

作　　者：朱周静 王艳娇[1] 仝红娟 ZHU Zhou-jing;WANG Yan-jiao;TONG Hong-juan(Xianyang Key Laboratory of Molecular Imaging and Drug Synthesis,School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xianyang 712046,China)

机构地区：[1]咸阳市分子影像与药物合成重点实验室,陕西国际商贸学院医药学院,陕西咸阳712046

出　　处：《化学工程师》2023年第5期1-4,9,共5页Chemical Engineer

基　　金：陕西省自然科学基础研究计划项目(2021JQ-885);咸阳市分子影像与药物合成重点实验室(2021QXNL-PT-0008)。

摘　　要：本文报道N-(4-溴-2,6-二氯苯基)吡嗪-2-胺(2)的合成及表征。在浓H2SO4存在的条件下,3-[(4-溴-2,6-二氯苯基)氨基]吡嗪-2-腈(1)脱除氰基,得到目标化合物N-(4-溴-2,6-二氯苯基)吡嗪-2-胺(2)。产物结构经过1H NMR、ESI-MS及XRD单晶衍射表征。考察反应条件发现,当浓H_(2)SO_(4)用量为n H2SO4∶n化合物(1)为10∶1,乙醇为反应溶剂,在80℃条件下反应10h,产物收率达到90.3%。The synthesis and characterization of N-(4-bromo-2,6-dichlorophenyl)pyrazin-2-amine(2)was reported.The target compound was synthesized by decyanation reaction of 3-(4-bromo-2,6-dichlorophenyl)amino pyrazine-2-carbonitrile(1)in the presence of sulfuric acid.The structure of the product was characterized by 1H NMR,ESI-MS and XRD single crystal diffraction.It was found that when the dosage of sulfuric acid was nH_(2)SO_(4)∶ncompound(1)为10∶1 and ethanol was used as the reaction solvent,the yield of product was up to 90.3%at 80℃ for 10h.

关 键 词：吡嗪衍生物 2-氨基吡嗪 水解反应 脱羧反应 

分 类 号：TQ463[化学工程—制药化工]