低分子肝素钙联合双嘧达莫治疗下肢骨折术后下肢深静脉血栓的效果分析  

Effect analysis of low molecular weight heparin calcium combined with dipyridamole in the treatment of lower extremity deep venous thrombosis after lower extremity fracture surgery

作　　者：孙明顶 SUN Ming-ding(Department of Orthopedics,Peixian County Hospital of Traditional Chinese Medicine,Xuzhou 221699,China)

机构地区：[1]江苏徐州沛县中医院骨科(七病区),221699

出　　处：《中国实用医药》2023年第10期124-126,共3页China Practical Medicine

摘　　要：目的 分析低分子肝素钙联合双嘧达莫治疗下肢骨折术后下肢深静脉血栓的临床效果。方法 74例下肢骨折术后下肢深静脉血栓患者,采用奇偶数分组法分为对照组和观察组,各37例。对照组采用双嘧达莫治疗,观察组采用低分子肝素钙联合双嘧达莫治疗。比较两组临床疗效,不良反应发生情况,术后全血粘度、血浆D-二聚体(D-D)、纤维蛋白原(FIB)水平及视觉模拟评分法(VAS)评分。结果 观察组总有效率为94.59%,高于对照组的75.68%,差异具有统计学意义(P<0.05)。术后3 d,观察组全血粘度为(9.76±1.67)mPa·s,血浆D-D为(223.15±22.45)μg/L,FIB为(3.16±0.26)g/L,对照组全血粘度为(12.57±1.51)mPa·s,血浆D-D为(279.13±28.89)μg/L,FIB为(3.45±0.45)g/L;术后7 d,观察组全血粘度为(4.29±0.74)mPa·s,血浆D-D为(152.81±26.24)μg/L,FIB为(2.55±0.29)g/L,对照组全血粘度为(9.38±0.97)mPa·s,血浆D-D为(213.18±21.39)μg/L,FIB为(2.94±0.38)g/L。术后3、7 d,观察组全血粘度、血浆D-D及FIB均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组VAS评分均低于治疗前,观察组VAS评分(1.29±0.65)分低于对照组的(1.67±0.71)分,差异有统计学意义(P<0.05)。观察组不良反应发生率5.41%低于对照组的29.73%,差异有统计学意义(P<0.05)。结论 下肢骨折术后下肢深静脉血栓患者使用低分子肝素钙联合双嘧达莫进行治疗可提高临床疗效,减少不良反应发生率,缓解患者疼痛,安全性高,值得临床推广应用。Objective To analyze the clinical effect of low molecular weight heparin calcium combined with dipyridamole in the treatment of lower extremity deep venous thrombosis after lower extremity fracture surgery.Methods A total of 74 patients with lower extremity deep venous thrombosis after lower extremity fracture surgery were divided into control group and observation group by odd-even grouping method,with 37 cases in each group.The control group was treated with dipyridamole,and the observation group was treated with low molecular weight heparin calcium and dipyridamole.Both groups were compared in terms of clinical efficacy,occurrence of adverse reactions,whole blood viscosity,plasma D-dimer(D-D),fibrinogen(FIB)level and visual analogue scale(VAS)score after surgery.Results The total effective rate of the observation group was 94.59%,which was higher than that of 75.68%of the control group,and the difference was statistically significant(P<0.05).3 d after surgery,the whole blood viscosity,plasma D-D and FIB were(9.76±1.67)mPa·s,(223.15±22.45)μg/L and(3.16±0.26)g/L in the observation group,and(12.57±1.51)mPa·s,(279.13±28.89)μg/L and(3.45±0.45)g/L in the control group.7 d after surgery,the whole blood viscosity,plasma D-D and FIB were(4.29±0.74)mPa·s,(152.81±26.24)μg/L and(2.55±0.29)g/L in the observation group,and(9.38±0.97)mPa·s,(213.18±21.39)μg/L and(2.94±0.38)g/L in the control group.3 and 7 d after surgery,the whole blood viscosity,plasma D-D and FIB in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,VAS score in both groups was lower than that before treatment in this group,and VAS score of(1.29±0.65)points in the observation group was lower than that of(1.67±0.71)points in the control group.The differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.41%,which was lower than that of 29.73%in the control group,and the difference was statis

关 键 词：低分子肝素钙 双嘧达莫 下肢骨折 下肢深静脉血栓 

分 类 号：R687.3[医药卫生—骨科学] R543.6[医药卫生—外科学]