补肾活血汤治疗胫骨骨折延迟愈合患者的效果及对局部血供、骨转换的影响  

Effect of Bushen Huoxue Decoction in the Treatment of Patients with Delayed Healing of Tibial Fracture and Its Influence on Local Blood Supply and Bone Turnover

作　　者：王齐康 李清智 WANG Qikang;LI Qingzhi(Fuzhou Economic and Technological Development Zone Hospital,Fuzhou 350000,China;不详)

机构地区：[1]福州经济技术开发区医院,福建福州350000

出　　处：《中外医学研究》2023年第15期113-117,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究补肾活血汤治疗胫骨骨折延迟愈合患者的效果及对局部血供、骨转换的影响。方法:选取2017年1月—2022年1月福州经济技术开发区医院收治的82例胫骨骨折延迟愈合患者。根据随机数表法将其分为对照组和观察组,各41例。对照组给予常规骨折延迟愈合治疗,观察组则在此基础上加用补肾活血汤。比较两组临床疗效,治疗前及治疗6周、12周后血液指标及骨转换指标、局部血供状态。结果:观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗6周、12周后,观察组可溶性细胞间黏附分子-1(sICAM-1)及可溶性血管细胞黏附分子-1(sVCAM-1)水平均显著低于对照组,差异有统计学意义(P<0.05)。治疗6周、12周后,观察组骨钙素N端中分子片段(N-MID)、β-胶原降解产物(β-CTX)及Ⅰ型胶原交联N-末端肽(NTX)水平均高于对照组,差异有统计学意义(P<0.05)。治疗6周、12周后,观察组流态积分、襻周积分、形态积分均显著低于对照组,差异有统计学意义(P<0.05)。结论:补肾活血汤治疗胫骨骨折延迟愈合患者的效果较好,且可显著改善患者的局部血供及骨转换状态,在胫骨骨折延迟愈合患者中的应用价值相对较高。Objective:To investigate the effect of Bushen Huoxue Decoction in the treatment of patients with delayed healing of tibial fracture and its influence on local blood supply and bone turnover.Method:A total of 82 patients with delayed healing of tibial fracture admitted to Fuzhou Economic and Technological Development Zone Hospital from January 2017 to January 2022 were selected. According to the random number table method, they were divided into control group and observation group, with 41 cases in each group. The control group was given conventional delayed fracture healing treatment, and the observation group was additionally given Bushen Huoxue Decoction on this basis. The clinical efficacy, blood indexes, bone turnover indexes and local blood supply status before treatment, after 6 weeks and 12 weeks of treatment of the two groups were compared. Result: The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). After 6 weeks and 12 weeks of treatment, soluble intercellular adhesion mo1ecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in observation group were significantly lower than those in control group, and the differences were statistically significant (P<0.05). After 6 weeks and 12 weeks of treatment, the levels of osteocalcin N-terminal molecular fragment (N-MID), β-C-terminal telopeptide of type- Ⅰ collagen (β-CTX) and type Ⅰ collagen cross-linked N-terminal peptide (NTX) in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). After 6 weeks and 12 weeks of treatment, the flow pattern scores, loop scores and morphological scores in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion: The effect of Bushen Huoxue Decoction in the treatment of patients with delayed healing of tibial fracture i

关 键 词：补肾活血汤 胫骨骨折 延迟愈合 局部血供 骨转换 

分 类 号：R274.1[医药卫生—中医骨伤科学]