高尿酸血症与高血压的内分泌代谢机制研究  

Study on Endocrine and Metabolic Mechanism of Hyperuricemia and Hypertension

作　　者：葛珂楠 骆宏[1] 寿岚[1] GE Kenan;LUO Hong;SHOU Lan(The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China;不详)

机构地区：[1]杭州师范大学附属医院,浙江杭州310015

出　　处：《中外医学研究》2023年第15期169-173,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：近些年来因生活习惯改变、饮食结构、医疗卫生条件改善及人均寿命增加,高尿酸血症(HUA)患病率呈全球性上升,且有年轻化的趋势,其是一种代谢异常疾病,可继发痛风、急性肾损伤、心血管疾病、代谢性疾病等。在人类演变及发展的过程尿酸可能具有广泛的作用,包括氧化、抗氧化、兴奋神经及免疫刺激等。因此HUA与临床疾病之间有着错综复杂的联系和不同的分子生物学机制。日益增多的前瞻性和临床研究均发现HUA为高血压等心血管疾病的危险因素,然而其是否为独立危险因素目前尚无统一结论。因此,应充分认识HUA在高血压的发生、发展中的存在性及危害性,及时做出正确的判断和治疗。本文主要从内分泌代谢角度分析HUA与高血压之间可能的机制,并对其进行简要的阐述。In recent years,due to the change of living habits,the improvement of diet structure,medical and health conditions and the increase of life expectancy,the prevalence of hyperuricemia(HUA)is on the rise globally and tends to be younger,it is a metabolic disorder that can lead to gout,acute kidney injury,cardiovascular disease,metabolic disease,etc.Uric acid may have a wide range of effects in the process of human evolution and development,including oxidation,antioxidation,nerve stimulation,and immune stimulation.Therefore,there are complex connections and different molecular biological mechanisms between HUA and clinical diseases.An increasing number of prospective and clinical studies have found that HUA is a risk factor for cardiovascular diseases such as hypertension,but there is currently no unified conclusion on whether it is an independent risk factor.Therefore,it is necessary to fully understand the existence and harmfulness of HUA in the occurrence and development of hypertension,and make timely and correct judgments and treatments.This article mainly analyzes the possible mechanism between HUA and hypertension from the perspective of endocrine metabolism,and briefly elaborates on it.

关 键 词：尿酸 高血压 代谢机制 

分 类 号：R589.7[医药卫生—内分泌] R544.1[医药卫生—内科学]