Chemically revised conducting polymers with inflammation resistance for intimate bioelectronic electrocoupling  

作　　者：Sihao Qian Hsing-An Lin Qichao Pan Shuhua Zhang Yunhua Zhang Zhi Geng Qing Wu Yong He Bo Zhu 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai,201620,China [2]School of Materials Science and Engineering&Shanghai Engineering Research Center of Organ Repair,Shanghai University,Shanghai,200444,China [3]Innovation Center for Textile Science and Technology,Donghua University,Shanghai,201620,China

出　　处：《Bioactive Materials》2023年第8期24-51,共28页生物活性材料（英文）

基　　金：supported by NSFC(22175111,21474014,21704013,and 51903149);the Program for Professor of Special Appointment(Eastern Scholar)at the Shanghai Institutions of Higher Learning(TP2019043);the Program of Shanghai Academic/Technology Research Leader(20XD1400100).

摘　　要：Conducting polymers offer attractive mixed ionic-electronic conductivity,tunable interfacial barrier with metal,tissue matchable softness,and versatile chemical functionalization,making them robust to bridge the gap between brain tissue and electronic circuits.This review focuses on chemically revised conducting polymers,combined with their superior and controllable electrochemical performance,to fabricate long-term bioelectronic implants,addressing chronic immune responses,weak neuron attraction,and long-term electrocommunication instability challenges.Moreover,the promising progress of zwitterionic conducting polymers in bioelectronic implants(≥4 weeks stable implantation)is highlighted,followed by a comment on their current evolution toward selective neural coupling and reimplantable function.Finally,a critical forward look at the future of zwitterionic conducting polymers for in vivo bioelectronic devices is provided.

关 键 词：Bioelectronic Conducting polymer ZWITTERION ANTIFOULING Inflammation resistance 

分 类 号：O63[理学—高分子化学]