Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia  

作　　者：Ming Li Yuan Gao Miaowen Jiang Hongkang Zhang Yang Zhang Yan Wu Wenhao Zhou Di Wu Chuanjie Wu Longfei Wu Luzi Bao Xiaoxiao Ge Zhengfei Qi Ming Wei Ang Li Yuchuan Ding Jicheng Zhang Guangzhen Pan Yu Wu Yan Cheng Yufeng Zheng Xunming Ji 

机构地区：[1]China-America Institute of Neuroscience and Beijing Institute of Geriatrics,Xuanwu Hospital,Capital Medical University,Beijing,100053,China [2]School of Instrumentation and Optoelectronic Engineering,Beihang University,Beijing,100191,China [3]Beijing Institute for Brain Disorders,Capital Medical University,Beijing,100069,China [4]School of Materials Science and Engineering,Peking University,Beijing,100871,China [5]Shaanxi Key Laboratory of Biomedical Metallic Materials,Northwest Institute for Nonferrous Metal Research,Xi’an,710016,China [6]Department of Biomedical Engineering,Columbia University,New York City,NY,10027,USA [7]Department of Neurosurgery,Wayne State University School of Medicine,Detroit,MI,48201,USA [8]Gong Yi Van-research Innovation Composite Material Co.Ltd,Zheng Zhou,451299,China [9]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing,100053,China

出　　处：《Bioactive Materials》2023年第8期116-127,共12页生物活性材料（英文）

基　　金：supported by National Natural Science Foundation of China(82102220,82027802,61975017,82071468);Beijing Municipal Science and Technology Commission(Z221100007422023);General Projects of Scientific and Technological Plan of Beijing Municipal Education Commission(KM202010025023);Talents Gathering Project of Xuanwu Hospital Capital Medical University.

摘　　要：Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection,but current catheters do not support thermally-insulated transfer of cold infusate,which results in an increased exit temperature,causes hemodilution,and limits its cooling efficiency.Herein,air-sprayed fibroin/silica-based coatings combined with chemical vapor deposited parylene-C capping film was prepared on catheter.This coating features in dual-sized-hollow-microparticle incorporated structures with low thermal conductivity.The infusate exit temperature is tunable by adjusting the coating thickness and infusion rate.No peeling or cracking was observed on the coatings under bending and rotational scenarios in the vascular models.Its efficiency was verified in a swine model,and the outlet temperature of coated catheter(75μm thickness)was 1.8-2.0◦C lower than that of the uncoated one.This pioneering work on catheter thermal insulation coatings may facilitate the clinical translation of selective endovascular hypothermia for neuroprotection in patients with acute ischemic stroke.

关 键 词：Silk fibroin Thermal insulation coating CATHETER STROKE HYPOTHERMIA 

分 类 号：R318[医药卫生—生物医学工程]