Hydrophobic aerogel-modified hemostatic gauze with thermal management performance  

作　　者：Xiaoli Jia Chao Hua Fengbo Yang Xiaoxiao Li Peng Zhao Feifan Zhou Yichi Lu Hao Liang Malcolm Xing Guozhong Lyu 

机构地区：[1]Engineering Research Center of the Ministry of Education for Wound Repair Technology,Jiangnan University,Affiliated Hospital of Jiangnan University,Wuxi,214000,China [2]Wuxi School of Medicine,Jiangnan University,Wuxi,214000,China [3]Medical School of Nantong University,Nantong,226019,China [4]Nanjing University of Traditional Chinese Medicine,Nanjing,210023,China [5]Changhai Clinical Research Unit,Shanghai Changhai Hospital,Naval Medical University,Shanghai,200433,China [6]Department of Mechanical Engineering,University of Manitoba,Winnipeg,R3T 2N2,Canada

出　　处：《Bioactive Materials》2023年第8期142-158,共17页生物活性材料（英文）

基　　金：granted approval by the Animal Ethics Committee of Jiangnan University(Protocol JN.No 20220615S0801025).

摘　　要：Current hemostatic agents or dressings are not efficient under extremely hot and cold environments due to deterioration of active ingredients,water evaporation and ice crystal growth.To address these challenges,we engineered a biocompatible hemostatic system with thermoregulatory properties for harsh conditions by combining the asymmetric wetting nano-silica aerogel coated-gauze(AWNSA@G)with a layer-by-layer(LBL)structure.Our AWNSA@G was a dressing with a tunable wettability prepared by spraying the hydrophobic nano-silica aerogel onto the gauze from different distances.The hemostatic time and blood loss of the AWNSA@G were 5.1 and 6.9 times lower than normal gauze in rat’s injured femoral artery model.Moreover,the modified gauze was torn off after hemostasis without rebleeding,approximately 23.8 times of peak peeling force lower than normal gauze.For the LBL structure,consisting of the nano-silica aerogel layer and a n-octadecane phase change material layer,in both hot(70℃)and cold(-27℃)environments,exhibited dual-functional thermal management and maintained a stable internal temperature.We further verified our composite presented superior blood coagulation effect in extreme environments due to the LBL structure,the pro-coagulant properties of nano-silica aerogel and unidirectional fluid pumping of [e-mail] work,therefore,shows great hemostasis potential under normal and extreme temperature environments.

关 键 词：Hydrophobic hemostasis Thermal management Hydrophobic methyl modified nano-silica aerogel Harsh environments Unidirectional fluid pumping 

分 类 号：TQ127.11[化学工程—无机化工]