Box-Behnken响应面法优化天麻胶囊挥发油包合工艺  

Optimization of Tianma Capsule Volatile Oil Inclusion Process Based on Box-Behnken Response Surface Method

作　　者：刘松鑫 周娜 庄园 吴成红 于祥玉 左瑞娟 武光云 卢传广 战瑞雪 关永霞 沈庆国 LIU Songxin;ZHOU Na;ZHUANG Yuan;WU Chenghong;YU Xiangyu;ZUO Ruijuan;WU Guangyun;LU Chuanguang;ZHAN Ruixue;GUAN Yongxia;SHEN Qingguo(Lunan Hope Pharmaceutical Co.,Ltd.,Linyi 276006,China;State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine of Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China;Archives of LinYi University,Linyi 276005,China;Linyi Pension Development Service Center,Linyi 276032,China)

机构地区：[1]鲁南厚普制药有限公司,山东临沂276006 [2]鲁南制药集团中药制药共性技术国家重点实验室,山东临沂276006 [3]临沂大学档案馆,山东临沂276005 [4]临沂市养老事业发展服务中心,山东临沂276032

出　　处：《现代中药研究与实践》2023年第2期72-76,共5页Research and Practice on Chinese Medicines

基　　金：山东省重点研发计划(重大科技创新工程)项目(2020CXGC010505);山东省新旧动能转换重大产业攻关项目(鲁动能办〔2021〕23号);临沂市兰山区科技创新发展计划专项(2026)。

摘　　要：目的筛选并优化天麻胶囊挥发油的包合工艺。方法以天麻胶囊挥发油包合物收率和包合率为指标,筛选天麻胶囊挥发油的包合方法,采用Box-Behnken响应面法,优化天麻胶囊挥发油包合的工艺条件。结果采用胶体磨包合法得到天麻胶囊挥发油最佳包合工艺条件为:β-环糊精∶天麻胶囊挥发油=9∶1,水∶β-环糊精=13∶1,包合时间为25 min。此条件下包封率为79.07%,收率为75.48%。结论优选的天麻胶囊挥发油胶体磨包合工艺效果较好,稳定可行,可用于工业化生产。Objective To screen and optimize the inclusion process of Tianma capsule volatile oil.Methods Inclusion method of Tianma capsule volatile oil was screened with the yield of inclusion compound and inclusion rate of volatile oil-β-cyclodextrin and Box-Behnken was used to optimize the colloid mill inclusion process of Tianma capsule volatile oil.Results The optimal colloid mill inclusion process of Tianma capsule volatile oil was as follows:the ratio ofβ-cyclodextrin to Tianma capsule volatile oil was 9∶1,the ratio of water toβ-cyclodextrin was 13∶1,and the inclusion time was 25 min.Under this condition,the inclusion rate was 79.07%and inclusion compound was 75.48%.Conclusion The inclusion process of Tianma capsule volatile oil by response surface method is better,stable and feasible.The model can be used for industrial production of the Tianma capsule volatile oil with colloid mill.

关 键 词：天麻胶囊 挥发油 响应面分析 胶体磨 

分 类 号：R283.3[医药卫生—中药学]