基于数据挖掘的中药外治专利复方治疗糖尿病足的用药规律分析  

Analysis of Drug Use Rules of Patent External Therapy of Traditional Chinese Medicine for Diabetic Foot Based on Data Mining

作　　者：张乃金 崔淮星 曾仙月 孙璇[1] 王泓午[1] ZHANG Naijin;CUI Huaixing;ZENG Xianyue;SUN Xuan;WANG Hongwu(School of Public Health,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学公共卫生与健康科学学院,天津301617

出　　处：《现代中药研究与实践》2023年第2期88-91,共4页Research and Practice on Chinese Medicines

基　　金：国家重点研发计划项目(2017YFC1703305);国家重点基础研究发展计划“973计划”项目(2011CB505406);中国工程院院地合作项目(21ZLGCGX00030)。

摘　　要：目的基于数据挖掘技术分析总结治疗糖尿病足中药外治专利复方的用药规律,为相关研究提供参考。方法选取中国国家知识产权局专利检索与分析系统,检索治疗糖尿病足的中药外治专利复方,运用Excel软件进行中药频次统计、四气五味及归经频数分析,采用SPSS Modeler 18.0、SPSS statistics 26.0软件进行高频药物关联规则分析、聚类分析。结果共纳入治疗糖尿病足的中药外治专利复方128个,中药429味;出现频次较高的前3位中药为当归、红花、乳香;出现频次最多的药物类别为清热药、活血化瘀药、止血药;四气以寒、温、平为主;五味以苦、辛、甘为主;归经以肝、肺、肾、脾经居多;关联规则排名靠前的药对有没药、黄柏-乳香,没药、红花-乳香,没药、当归-乳香等;核心药物网络由30味中药组成;聚类分析共得到7类药物组成和2个单味药。结论治疗糖尿病足的中药外治专利复方多用苦寒,辛温、甘温之药,多以活血化瘀、补虚清热为法,合理辨证后可选用不同核心药物组合以论治。Objective To analyze and summarize the medication rules of the external patent compound prescription of traditional Chinese medicine for the treatment of diabetic foot based on the data mining technology,and provide reference for related research.Methods The patent retrieval and analysis system of the State Intellectual Property Office of the People’s Republic of China was selected to retrieve the external treatment patent compound prescription of traditional Chinese medicine for treating diabetic foot.Excel software was used to conduct frequency statistics of traditional Chinese medicine,four nature and five flavors of drugs and frequency analysis of meridian tropism.SPSS Modeler 18.0 and SPSS statistics 26.0 software were used to conduct high-frequency drug association rule analysis and cluster analysis.Results A total of 128 Chinese herbal external treatment patent compounds were included in the treatment of diabetic foot,including 429 Chinese herbal medicines.The first three Chinese medicines with high frequency were Angelica,Safflower and Frankincense.The drugs with the highest frequency were heat clearing drugs,blood activating and stasis removing drugs,and hemostatic drugs.The four nature were mainly cold,warm and calm.The five flavors were mainly bitter,bitter and sweet.Liver,lung,kidney and spleen meridians are the main meridians.The top drug pairs in association rules were myrrh,phellodendron frankincense,myrrh,safflower frankincense,myrrh,angelica frankincense,etc.The core drug network consists of 30 traditional Chinese medicines.The cluster analysis obtained 7 kinds of drug compositions and 2 single drugs.Conclusion The patent compound of Chinese medicine for external treatment of diabetic foot mainly uses bitter cold,pungent and sweet drugs,which are mainly used to promote blood circulation and remove blood stasis,and to replenish deficiency and clear away heat.After rational syndrome differentiation,different core drug combinations are selected for treatment.

关 键 词：数据挖掘 糖尿病足 中药外治 专利 关联规则 聚类 

分 类 号：R285.6[医药卫生—中药学]