孕妇羊水及尿中DEHP水平与胎膜早破及血清中炎症介质的关系研究  

Investigating the relationship between the exposure level of DEHP in amniotic fluid and urine and the occurrence of premature rupture of membranes and serum inflammatory mediators

作　　者：韩愈 王晓艳[1] 陈晓璐[1] 卢彩玲[1] HAN Yu;WANG Xiaoyan;CHEN Xiaolu;LU Cailing(Department of Obstetrics and Gynaecology,Taizhou First People's Hospital,Zhejiang 318020,China)

机构地区：[1]台州市第一人民医院妇产科,浙江318020

出　　处：《工业卫生与职业病》2023年第3期252-254,262,共4页Industrial Health and Occupational Diseases

基　　金：浙江省台州市科技计划项目(1701KY50)。

摘　　要：目的探索孕妇羊水及尿中邻苯二甲酸二(2-乙基己基)酯(di(2-ethylhexyl)phthalate,DEHP)水平与孕妇胎膜早破及血清中炎症介质的关系。方法将我院2018年1月至2020年9月收治的105例胎膜早破患者作为观察组,105例正常健康孕妇作为对照组;采用HPLC法检测孕妇羊水及尿中DEHP水平、血清中IL-6和CRP水平;应用spearman相关性检验分析羊水和尿中DEHP水平与胎膜早破的关系,采用一元线性回归模型分析羊水和尿中与血清中炎症因子相关性。结果观察组羊水和尿中DEHP水平明显高于对照组(6.82±0.54比1.98±0.42,4.62±0.75比1.02±0.32)(t=51.748、45.240,P<0.05);观察组血清中IL-6和CRP水平明显高于对照组(41.93±3.98比30.84±4.29,13.82±1.43比8.23±0.62)(t=15.635、36.751,P<0.05);观察组羊水和尿中DEHP水平与孕妇胎膜早破呈明显正相关关系(r=0.743、0.698,P<0.05);观察组羊水和尿中DEHP与血清中IL-6和CRP水平呈明显正相关关系,且线性关系良好(R^(2)>0.95)。结论孕妇羊水及尿中DEHP暴露水平与孕妇胎膜早破的发生及血清中炎症因子水平呈明显正相关关系。Objective To analyze the relationship between the exposure level of DEHP in amniotic fluid and urine from pregnant women and the occurrence of premature rupture of membranes and serum inflammatory mediators.Methods A total of 105 cases of patients with premature rupture of membranes in our hospital from January 2018 to September 2020 were selected as the observation group,and 105 cases of pregnant women were selected as the control group;the levels of DEHP in amniotic fluid and urine of pregnant women were detected by HPLC;the levels of IL-6 and CRP in blood were detected;the relationship between DEHP levels in amniotic fluid and urine samples and premature rupture of membranes was analyzed by Spearman correlation test,and the blood samples were analyzed by univariate lin⁃ear regression model There was correlation between inflammatory factors in urine and serum.Results The levels of DEHP in amniotic fluid and urine in the observation group were significantly higher than those in the control group(6.82±0.54 vs 1.98±0.42,4.62±0.75 vs 1.02±0.32)(t=51.748、45.240,P<0.05);The levels of serum IL-6 and CRP in the observation group were significantly higher than those in the control group(41.93±3.98 vs 30.84±4.29;13.82±1.43 vs 8.23±0.62)(t=15.635、36.751,P<0.05);The levels of DEHP in amniotic fluid and urine in the observation group were significantly positively correlated with premature rupture of membranes(r=0.743、=0.698,P<0.05);There was a significant positive correlation between DEHP in amniotic fluid and urine and the levels of serum IL-6 and CRP in the observation group,and the linear relationship was good(R^(2)>0.95).Conclusion The exposure level of DEHP in amniotic fluid and urine of pregnant women is positively correlated with the occurrence of premature rupture of membranes and serum inflammatory factors.

关 键 词：羊水 尿液 邻苯二甲酸二(2-乙基己基)酯 胎膜早破 炎症介质 

分 类 号：R714.4[医药卫生—妇产科学]