生物标志物在妊娠期糖尿病患者早产预测中的研究进展  

Advances in the early predictive value of biomarkers in preterm delivery induced by gestational diabetes mellitus

作　　者：袁琳[1] 朱雯雯 崔县伟[2] 钟天鹰[1] YUAN Lin;ZHU Wenwen;CUI Xianwei;ZHONG Tianying(Department of Clinical Laboratory,Women’s Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China;Nanjing Maternity and Child Health Care Institute,Women’s Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)检验科,江苏南京210004 [2]南京医科大学附属妇产医院(南京市妇幼保健院)医学研究中心,江苏南京210004

出　　处：《南京医科大学学报（自然科学版）》2023年第5期738-744,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生健康委医学科研立项项目(K2019014)。

摘　　要：妊娠期糖尿病(gestational diabetes mellitus,GDM)是一种常见的产科并发症,易导致早产等严重不良妊娠结局的发生,进而增加新生儿转归不良的风险,严重威胁新生儿的健康。因此及早的筛查、诊断对于GDM早产意义重大。本文简述了近年国内外有关GDM孕妇早产的筛查及预测方法,系统性分析了常规及新型生物标志物在GDM孕妇早产中的预测价值,以期为建立合理的GDM孕妇早产预测模型提供依据,从而实现早诊断、早干预,改善母婴结局。Gestational diabetes mellitus(GDM)is a common obstetric complication that can easily lead to the occurrence of serious adverse pregnancy outcomes,including preterm birth,high risk of poor outcomes in newborns and seriously threatening the health of newborns.Early screening and diagnosis are critical for preterm birth in GDM pregnant women.In this review,the screening and prediction methods for preterm birth in GDM pregnant women at home and abroad in recent years are briefly summarized,and the predictive values of routine and novel biomarkers in preterm birth of GDM pregnant women is systematically summarized,in order to provide a basis for establishing a reasonable prediction model for preterm birth of GDM pregnant women,so as to achieve early diagnosis and intervention,as well as improve maternal and infant outcomes.

关 键 词：妊娠期糖尿病 早产 早期预测 生物标记物 

分 类 号：R714.15[医药卫生—妇产科学]