补益脾肾法治疗非小细胞肺癌癌因性疲乏  

Treatment of Cancer-Related Fatigue of Non-Small Cell Lung Cancer with Tonifying Spleen and Kidney Method

作　　者：李黎[1] 张晗 刘馨雁[1] 朴炳奎[1] LI Li;ZHANG Han;LIU Xinyan;PIAO Bingkui(Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing China 100053)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中医学报》2023年第6期1291-1295,共5页Acta Chinese Medicine

摘　　要：目的:观察补益脾肾方药对非小细胞肺癌患者化疗后癌因性疲乏的影响。方法:将84例非小细胞肺癌患者按照抽签的方法分为治疗组和对照组,两组患者均采用AP治疗方案化疗,21 d为1个周期,治疗组在特定化疗方案基础上联合补益脾肾方药。对照组在特定化疗方案基础上联合地塞米松治疗。分别于化疗前、化疗结束、化疗后7 d评估患者疲乏程度以及白细胞、血红蛋白和血清白蛋白水平。结果:两组患者临床疗效比较,治疗组有效率(100.0%)高于对照组(95.2%)。治疗组治疗前后比较,疲乏评分均有改善,差异具有统计学意义(P<0.05);对照组治疗前后比较,行为疲乏评分和躯体疲乏评分较治疗前增加,且差异具有统计学意义(P<0.05),而认知疲乏评分和情感疲乏评分未见明显改变,表明治疗组较对照组治疗效果理想。治疗后,对照组与治疗组白细胞计数及血红蛋白水平较治疗前均显著下降,差异具有统计学意义(P<0.05)。治疗后,治疗组患者的CD4细胞百分比、CD8细胞百分比与对照组比较,差异具有统计学意义(P<0.05);治疗组CD4细胞百分比、CD8细胞百分比较治疗前显著改善,差异有统计学意义(P<0.05)。结论:补益脾肾方药对改善非小细胞肺癌化疗后疲乏有一定疗效,能够提高患者生活质量。Objective:To observe the effect of tonifying Spleen and Kidney method on cancer-related fatigue(CRF)after chemotherapy in patients with non-small cell lung cancer.Methods:84 patients with NSCLC were divided into a treatment group and a control group by drawn method.Both groups were treated with AP regimen chemotherapy with 21d for one cycle.The treatment group was treated with tonifying Spleen and Kidney prescription based on specific chemotherapy regimens.The control group was treated with dexamethasone in combination with specific chemotherapy regimens.Patient fatigue and white blood cell,hemoglobin,and serum albumin levels were assessed before,after,and the 7th day after chemotherapy,respectively.Results:The clinical efficacy of the two groups was higher in the treatment group(100%)than in the control group(95.2%).Comparing fatigue scores before and after treatment,the difference was statistically significant(P<0.05).comparing behavioral fatigue scores and somatic fatigue scores before and after treatment,the difference was statistically significant(P<0.05).However,there was no significant change in the cognitive fatigue score and emotional fatigue score,indicating that the treatment group had an ideal treatment effect compared to the control group.After treatment,WBC counts and hemoglobin levels were significantly reduced in the control group compared to the same group before treatment,with statistically significant differences(P<0.05).After treatment,the percentage of CD4 cells and CD8 cells in the treatment group was statistically significant(P<0.05)compared to the control group.The percentage of CD4 cells and the percentage of CD8 cells in the treatment group were significantly improved compared to pre-treatment,with statistically significant differences(P<0.05).Conclusion:Tonifying Spleen and Kidney method is effective in improving fatigue after chemotherapy of NSCLC and can improve the quality of life of patients.

关 键 词：癌因性疲乏 非小细胞肺癌 补益脾肾法 脾肾阳虚证 

分 类 号：R273[医药卫生—中西医结合]