复发性流产与LncRNA-H19表达升高的关联性研究  

Association study of recurrent miscarriage and elevated LncRNA-H19 expression

作　　者：韦桂喜 李伟[2] 莫武宁[1] 徐鹏[2] Wei Guixi;Li Wei;Mo Wuning;Xu Peng(Department of Clinical Laboratory,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Clinical Laboratory,Liuzhou People′s Hospital,Liuzhou 545001,China)

机构地区：[1]广西医科大学第一附属医院检验科,广西南宁530021 [2]柳州市人民医院检验科,广西柳州545001

出　　处：《实用妇科内分泌电子杂志》2022年第36期10-12,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(编号Z20200464)(编号Z20200395)。

摘　　要：目的 分析复发性流产与LncRNA-H19表达升高的相关性。方法 选取50例复发性流产患者,同时选取因意外妊娠实施人工流产手术的50例患者作为研究对象,对其胚胎组织中的LncRNA-H19表达水平进行检测。结果 经检测复发性流产患者胚胎组织中的LncRNA-H19表达水平高于流产手术患者(P<0.05)。结论 复发性流产患者胚胎组织中的LncRNA-H19表达水平显著提升,即LncRNA-H19表达升高与复发性流产具有直接关系。Objective To analyze the association of recurrent abortion and the elevated expression of LncRNA-H19.Methods A total of 50 patients with recurrent abortion and 50 patients with induced abortion due to unintended pregnancy were selected as research objects.The expression level of LncRNA-H19 in their embryonic tissues was detected.Results The expression level of LncRNA-H19 in embryo tissue of recurrent abortion patients was higher than that of abortion patients(P<0.05).Conclusion The expression level of LncRNA-H19 is significantly increased in the embryonic tissues of the recurrent abortion patients,namely,the elevated expression of LncRNA-H19 is directly related to the recurrent abortion.

关 键 词：复发性流产 LncRNA-H19表达 关联性 

分 类 号：R714.21[医药卫生—妇产科学]