低分子肝素与黄体酮联合叶酸治疗复发性流产的效果分析  

Effect analysis of Low Molecular Weight Heparin and Progesterone combined with Folic Acid in the treatment of recurrent abortion

作　　者：张晓娟[1] Zhang Xiaojuan(Department of Obstetrics and Gynecology,the Third Staff Hospital of Baotou Steel Group Inner Mongolia,Baotou 014010,China)

机构地区：[1]内蒙古包钢集团第三职工医院妇产科,内蒙古包头014010

出　　处：《实用妇科内分泌电子杂志》2022年第36期58-60,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的 研究复发性流产患者接受低分子肝素与黄体酮联合叶酸治疗的效果。方法 选取84例复发性流产患者作为研究对象,采用电脑随机分组法分为对照组与研究组,各42例。对照组采用黄体酮治疗,研究组采用低分子肝素与黄体酮联合叶酸治疗,比较两组患者的凝血功能、激素水平、活产率。结果 治疗前,两组患者的纤维蛋白(原)降解产物(FDP)、D-二聚体、纤维蛋白原(FIB)、P选择素水平比较,差异无统计学意义(P>0.05);治疗后,研究组的FDP、D-二聚体、FIB、P选择素水平明显低于对照组(P<0.05)。治疗前,两组患者的血清β-人绒毛膜促性腺激素(β-HCG)、孕激素、雌二醇(E_(2))水平比较,差异无统计学意义(P>0.05);治疗后,研究组的β-HCG、孕激素、E_(2)水平均明显高于对照组(P<0.05);研究组的活产率为97.62%,明显高于对照组的85.71%(P<0.05)。结论 复发性流产患者接受低分子肝素与黄体酮联合叶酸治疗后的保胎效果较理想,不仅可以提高β-HCG、孕激素水平,而且可以使早期胚胎发育状态得到优化,提升其活产率。Objective To study the effect of Low Molecular Weight Heparin and Progesterone combined with Folic Acid in the treatment of patients with recurrent abortion.Methods A total of 84 patients with recurrent abortion were selected as research objects and divided into the control group and the study group according to computer randomized method,with 42 cases in each group.The control group was treated with Progesterone,and the study group was treated with Low Molecular Weight Heparin and Progesterone combined with Folic Acid,The clotting function,hormone levels and live birth rate of the two groups were compared.Results Before treatment,there were no statistical significances in the levels of fibrin degradation product(FDP),D-dimer,fibrinogen(FIB) and P-selectin between 2 groups(P>0.05).After treatment,the levels of FDP,D-dimer,FIB and P-selectin in the study group were significantly lower than those in the control group(P<0.05).Before treatment,there was no significant differences in the levels of β-human chorionic gonadotropin(β-HCG),progesterone and estradiol(E_(2)) between the two groups(P<0.05).After treatment,the levels of β-HCG,progesterone and E_2 in the study group were significantly higher than those in the control group(P>0.05).The live birth rate of the study group was 97.62%,which was significantly higher than that of the control group(85.71%)(P<0.05).Conclusion Low Molecular Weight Heparin combined with Progesterone and Folic Acid therapy in patients with recurrent abortion has an ideal fetal preservation effect,which can not only effectively improve the levels of β-HCG and progesterone,optimize the early embryonic development state,and improve the treatment efficiency.

关 键 词：低分子肝素 黄体酮 叶酸治疗复发性流产 活产率 

分 类 号：R714.21[医药卫生—妇产科学]