机械应力对成骨细胞影响的研究进展  

Research progress on the impacts of mechanical stress on osteoblast

作　　者：张翔 周立亚 王仁杰 ZHANG Xiang;ZHOU Liya;WANG Renjie(Medical School,Hubei Minzu University,Hubei,Enshi 445000,China;Xiangyang Hospital of Traditional Chinese Medicine,Hubei,Xiangyang 441000,China)

机构地区：[1]湖北民族大学医学部,湖北恩施445000 [2]湖北省襄阳市中医医院,湖北襄阳441000

出　　处：《中国医药科学》2023年第10期58-61,共4页China Medicine And Pharmacy

基　　金：湖北省卫生健康委员会中医药科研项目(ZY2021M050)。

摘　　要：成骨细胞(OB)是骨形成的主要功能细胞,负责机体骨基质的合成、分泌以及矿化。机械应力(MS)是指物体受到外力而发生变形时,在物体内各部分之间产生相互作用的内力。随着世界人口老年化的加剧,老年性骨病已经成为全球性的医疗卫生问题,同时伴随着科技的进步,生物组织工程学、航空航天等领域对MS对于成骨细胞影响的研究也提出了更高要求。本文将阐述OB在流体剪切应力、压缩应力、牵张力和微重力不同MS刺激下的反应。Osteoblast(OB) is the main functional cell of bone formation,which is responsible for the synthesis,secretion and mineralization of bone matrix.Mechanical stress(MS) refers to the internal force that produces interaction between parts in an object when the object is deformed due to external force.With the intensification of the aging of the world population,senile osteopathy has become a global medical and health issue.Simultaneously,with the progress of science and technology,higher requirements have also been put forward on the research on the impact of MS on OB in the fields of biological tissue engineering,aerospace and so on.In this paper,the response of OB under different mechanical stresses such as fluid shear stress,microgravity,compressive stress,tractive tension and microgravity,will be elaborated.

关 键 词：流体剪切应力 压缩应力 牵张力 微重力 成骨细胞 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]