川崎病抗血小板药物的应用和监测  

Application and monitoring of antiplatelet drugs in children with Kawasaki disease

作　　者：史华旭(综述) 王虹(审校)[1] Shi Huaxu;Wang Hong(Pediatric Department of Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院儿内科,沈阳110004

出　　处：《国际儿科学杂志》2023年第4期253-256,共4页International Journal of Pediatrics

基　　金：辽宁省科技厅资助课题(2013225089)。

摘　　要：长期抗血小板治疗对川崎病患儿十分关键,常用的抗血小板药物各有其优势及不良反应,需谨慎选择。有研究表明川崎病患儿抗血小板治疗过程中可出现药物抵抗作用,增加了心血管不良事件的风险,因此,在用药期间需对血小板聚集功能进行监测。该文就川崎病常用的抗血小板药物、抗血小板药物的药物抵抗作用以及血小板聚集功能的检测方法进行综述,以提高临床医生的用药安全性,减少患儿并发症的发生。Long-term antiplatelet therapy is critical for children with Kawasaki disease.Commonly used antiplatelet drugs have their own advantages and adverse reactions,so they need to be chosen carefully.Some studies have shown that drug resistance may occur in children with Kawasaki disease during antiplatelet therapy,which increases the risk of cardiovascular adverse events,and platelet aggregation function needs to be monitored during medication.This paper reviews the antiplatelet drugs in common use,the drug resistance of antiplatelet drugs and the detection methods of platelet aggregation function in Kawasaki disease,which is helpful to improve the safety of drugs use and reduce the incidence of complications in children.

关 键 词：川崎病 冠状动脉损伤 抗血小板药物 血小板聚集功能 阿司匹林抵抗 

分 类 号：R725.4[医药卫生—儿科]