生酮饮食疗法的不良反应及防治的研究进展  

Progress on adverse reactions and prevention and treatment of ketogenic diet therapy

作　　者：马变慧(综述) 廖建湘(审校)[1] Ma Bianhui;Liao Jianxiang(Department of Neurology,China Medical University Shenzhen Children′s Hosptial,Shenzhen 518038,China)

机构地区：[1]中国医科大学深圳市儿童医院神经内科,518038

出　　处：《国际儿科学杂志》2023年第4期272-276,共5页International Journal of Pediatrics

基　　金：深圳市医疗卫生三名工程(SZSM201812005)。

摘　　要：生酮饮食(ketogenic diet,KD)是一种脂肪高比例、碳水化合物低比例、蛋白质和其它营养素适量的配方饮食,几个世纪以来一直被用于难治性癫痫的治疗。近年来,KD被证实在治疗其他疾病方面疗效明显,如肌萎缩侧索硬化症、创伤性脑损伤、糖尿病、肥胖症等。尽管KD对多种疾病的治疗具有积极效果,但由于其营养结构的不均衡性,所带来的短期及长期不良反应同样不可忽视。该文综述KD在治疗儿童难治性癫痫出现的不良反应及相应的防治措施,为临床安全高效实施KD提供参考。Ketogenic diet(KD)is a formulation diet with a high proportion of fat,low proportion of carbohydrates,appropriate protein and other nutrients,which has been used for centuries in the treatment of refractory epilepsy.In recent years,KD has been shown to be effective in the treatment of other diseases,such as amyotrophic lateral sclerosis,traumatic brain injury,diabetes,obesity,etc.Although KD has a positive effect on the treatment of a variety of diseases,the short-term and long-term adverse reactions caused by the imbalance of its nutritional structure should not be ignored.This article reviews the adverse reactions of KD in the treatment of children with refractory epilepsy and the corresponding prevention and treatment measures,to guide safe and efficient implementation of KD therapy in the clinic.

关 键 词：儿童 生酮饮食 癫痫 不良反应 

分 类 号：R459.3[医药卫生—治疗学]