肉苁蓉苯乙醇苷的抗肿瘤作用  

Anti-tumor Effects of Phenylethanoid Glycosides Deprived from Cistanche deserticola

作　　者：唐颖 武建强 TANG Ying;WU Jianqiang(College of Basic Medicine,Inner Mongolia Medical University,Hohhot 010110,China)

机构地区：[1]内蒙古医科大学基础医学院,呼和浩特010110

出　　处：《生物技术进展》2023年第3期399-405,共7页Current Biotechnology

基　　金：内蒙古自治区科技厅项目(2019GG037;2022MS08009);内蒙古医科大学肿瘤免疫创新人才团队项目(QNLC-2020006)。

摘　　要：恶性肿瘤一直都是世界公认的危害人类健康的重大公共卫生问题,随着社会老龄化进程的加快及一些其他因素的影响,各种恶性肿瘤的发病率都呈现上升趋势,且大部分肿瘤发现时就已经进入晚期,疾病进展快,预后差。虽然近年来肿瘤治疗的新疗法不断涌现,且疗效显著,但仍存在不良反应严重、部分患者无效等问题。因此,多方面探索、开发抗肿瘤效果强、不良反应小且不容易耐药的新药候选化合物,特别是中草药来源的生物活性分子,具有很好的临床现实意义。苯乙醇苷类(cistanche deprived phenylethanol glycosides,CPhGs)是中药材肉苁蓉(荒漠肉苁蓉,Cistanche deserticola)中含有的一类活性成分,研究表明其具有抗肿瘤、免疫调节、抗氧化等多种生物学功能,展现出良好的应用前景。对肉苁蓉苯乙醇苷类的抗肿瘤作用和机制及目前的科学认识进行了简要总结,以期为肉苁蓉及其苯乙醇苷类萃取物的进一步研究及临床应用提供参考。Malignant tumors have always been recognized as a major public health problem that threaten human health in the world.With the acceleration of the social aging and the influence of some other factors,the incidence of various malignant tumors has gradually shown an upward trend,and most of the tumors have entered the advanced stage when they were found,with rapid disease progression and poor prognosis.Although new therapies for tumor treatment have emerged in recent years and many of them have encouraging effects,there are still problems such as large side effects and ineffectiveness in some patients.Therefore,it is of great clinical significance to explore and develop new drug candidate compounds with strong anti-tumor effect,small side effects and not easy to drug resistance,especially bioactive molecules from Chinese herbal medicine.Cistanche deprived phenylethanol glycosides(CPhGs)is a class of active ingredients contained in the Chinese herb Cistanche deserticola.Recent studies have shown that it has anti-tumor,immunomodulatory,antioxidant and other biological functions,and has good application prospects.Here,the research results and current scientific understanding of the anti-tumor effect and mechanism of phenylethanoid glycosides in Cistanche deserticola were briefly reviewed in order to promote the further research and clinical application of Cis⁃tanche deserticola and its phenylethanoid glycosides extracts.

关 键 词：肉苁蓉 肉苁蓉苯乙醇苷 肿瘤 细胞增殖与凋亡 

分 类 号：R285[医药卫生—中药学]