Au@Ag NCs的制备及对痕量盐酸苯乙双胍的SERS检测  

Preparation of Au@Ag NCs and SERS detection of trace phenformin hydrochloride

作　　者：范维维 张艺欣 郑豆豆 汪胜 栾龙龙 徐维平 FAN Wei-wei;ZHANG Yi-xin;ZHENG Dou-dou;WANG Sheng;LUAN Long-long;XU Wei-ping(College of Pharmacy,Anhui University of Traditional Chinese Medicine,Hefei 230012,China;College of Chemistry and Chemical Engineering,Hefei University of Technology,Hefei 230009,China;Department of Geriatrics,Gerontology Institute of Anhui Province,The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Hefei 230001,China;Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy,Hefei 230001,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230012 [2]合肥工业大学化学与化工学院,安徽合肥230009 [3]中国科学技术大学附属第一医院(安徽省立医院)安徽省老年医学研究所老年医学科,安徽合肥230001 [4]肿瘤免疫与营养治疗安徽省重点实验室,安徽合肥230001

出　　处：《应用化工》2023年第5期1598-1601,1614,共5页Applied Chemical Industry

基　　金：国家自然科学基金项目(52072360);安徽省科技攻关项目(1804h08020252)。

摘　　要：建立了一种快速检测痕量盐酸苯乙双胍的检测平台。首先制备了金种子溶液,然后进一步制备小金八面体种子液,通过种子生长法得到金纳米立方体(Au NCs)。用二叔丁氧基二乙酰氧基硅烷对其进行絮凝纯化,再生长一层银壳,得到了双金属银包金纳米立方体(Au@Ag NCs),该基底对盐酸苯乙双胍的检测限为200 ng/mL,某在售中成药中添加盐酸苯乙双胍的最低掺杂量为0.05μg/mg,远超该掺杂药品每天的最低有效量。因此该基底为药物掺杂的检测提供了一种快速、简便、低廉、有效的方法。A rapid detection platform was established for the determination of trace phenformin hydrochloride.The Au seed solution was synthesized,then the small Au octahedron seed solution was further synthesized,and Au nanocubes(Au NCs)were obtained by seed growth method.It was flocculated and purified with di tert butoxy diacetoxy silane(BDAC),and a layer of Ag shell was regenerated to obtain bimetallic Ag coated Au nanocubes(Au@Ag NCs).The detection limit of the substrate for phenformin hydrochloride was as low as 200 ng/mL.The amounts of phenformin hydrochloride were added to a Chinese patent medicine on sale.The lowest detectable doping amount was 0.05μg/mg,far exceeding the lowest daily effective amount of the doped drug.Therefore,the substrate provides a fast,simple,cheap and effective method for the detection of drug doping.

关 键 词：表面增强拉曼光谱(SERS) Au@Ag NCs 盐酸苯乙双胍 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.37[化学工程—制药化工]