脊髓损伤基础研究存在的问题及改进建议  

Basic researches over spinal cord injury:problems and countermeasures

作　　者：赵书杰 陈建[1,2,3] 殷国勇[1,2,3] Zhao Shujie;Chen Jian;Yin Guoyong(Department of Orthopedics,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Jiangsu Institute of Functional Reconstruction and Rehabilitation,Nanjing 210029,China;Spinal Cord Disease Research Center,Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院骨科,南京210029 [2]江苏省功能重建与康复研究所,南京210029 [3]南京医科大学脊柱脊髓疾病研究中心,南京210029

出　　处：《中华创伤杂志》2023年第5期408-414,共7页Chinese Journal of Trauma

摘　　要：脊髓损伤致死率和致残率极高,其治疗一直是世界难题。随着医疗救治手段的进步,脊髓损伤患者的生存率有所提高,但脊髓损伤的临床疗效仍不理想。中国在脊髓损伤基础研究方面取得了重要进展,如解析脊髓损伤修复机制、研发多种细胞疗法和生物支架等治疗脊髓损伤。然而,部分基础研究对脊髓损伤微环境和动物模型认识不足或缺乏临床问题支撑,导致研究结论过于浅显甚至互相矛盾,迫切需要重新审视研究方法,开展基础研究与临床转化相结合的研究。为此,笔者探讨脊髓损伤基础研究存在的关键问题和困难,并提出改进建议,为正确开展基础研究和加速临床创新转化提供新思路。Spinal cord injury leads to extremely high mortality and disability rates and its treatment has always been a global challenge.The survival of patients with spinal cord injury is partially lengthened with the development of medical treatments,but the clinical outcome is still not satisfactory.Some important progress has been made in the basic researches over spinal cord injury,such as analysis of repair mechanism of spinal cord injury and development of cellular therapies and biological scaffolds of spinal cord injury in China.However,some basic researches show insufficient understanding of the microenvironment and animal model of spinal cord injury and lack support from clinical problems,leading to too simplistic or contradictory conclusions.There is an urgent need to reexamine the research methods and carry out basic and clinical translational researches.Therefore,the authors discuss the key problems and difficulties in basic researches over spinal cord injury and propose improvement suggestions,aiming to provide a reference for conducting basic researches correctly and accelerating clinical innovational transformation.

关 键 词：脊髓损伤 模型 动物 临床研究 

分 类 号：R651.2[医药卫生—外科学]