植物体内叶酸代谢及生物强化研究进展  

Research Progress in Folate Metabolism and Bioenhancement of Plants

作　　者：顾益银 韩莹琰 Gu Yiyin;Han Yingyan(Beijing Key Laboratory of New Technology in Agricultural Application,College of Plant Science and Technology,Beijing University of Agriculture,Beijing,102206)

机构地区：[1]北京农学院植物科学技术学院,农业应用新技术北京市重点实验室,北京102206

出　　处：《分子植物育种》2023年第11期3778-3784,共7页Molecular Plant Breeding

基　　金：现代农业产业技术体系北京市叶类蔬菜创新团队项目(BAIC 07-2021)资助。

摘　　要：叶酸(Folates)是四氢叶酸(THF)及其衍生物的总称,作为多数生物体内一碳单位的供体和受体,参与了很多重要的生理生化反应。若人类缺乏叶酸会导致许多疾病的发生,然而在人体中无法自主合成叶酸,主要从植物中摄取。近几十年来,利用生物技术手段对植物进行叶酸生物强化育种,提高植物体内叶酸含量,已成为解决全球性的叶酸缺乏症的最新选择。本研究介绍了植物叶酸代谢通路以及植物中叶酸的生物强化过程,并做出了展望,为今后通过代谢工程技术改良作物提供一些参考。Folates are general terms of tetrahydrofolate(THF)and its derivatives.As one-carbon unit donors and acceptors in most organisms,folates are involved in many important physiological and biochemical reactions.The deficiency of folates in human bodies will lead to many diseases.However,folates cannot be actively synthesized in the human bodies,so people extract folates mainly from plants.In recent decades,folate bioenhancement breeding of crops by means of biotechnology to increase folate content in crops has become the latest choice to solve folate deficiency worldwide.In this study,the pathway of plant folate biosynthesis and catabolism as well as the biofortification of folate were described,and the prospect was also given,which could provide some references for the improvement of crops through metabolic engineering technology in the future.

关 键 词：叶酸 代谢 蝶呤 对氨基苯甲酸 生物强化 

分 类 号：Q945[生物学—植物学]