藏药肉果草中1对新的木脂素苷  

A pair of new lignan glycosides from Tibetan medicine Lancea tibetica

作　　者：王俊林 张炜 尚宇欣 李文博 唐璐 朱怡 赵伟伊 苏艳芳[1] WANG Jun-lin;ZHANG Wei;SHANG Yu-xin;LI Wen-bo;TANG Lu;ZHU Yi;ZHAO Wei-yi;SU Yan-fang(School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China;Qinghai Institute of Medicinal Product Inspection and Detection,Xining 810016,China)

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]青海省药品检验检测院,青海西宁810016

出　　处：《中草药》2023年第10期3049-3053,共5页Chinese Traditional and Herbal Drugs

基　　金：天津市科技计划项目(20ZXGBSY00050)。

摘　　要：目的研究肉果草Lancea tibetica的化学成分。方法综合应用硅胶、Sephadex LH-20和制备液相等多种色谱方法进行分离纯化,并根据化合物NMR谱、MS谱等数据进行结构鉴定。采用斑马鱼炎症模型进行抗炎活性评价。结果从肉果草乙醇提取物的醋酸乙酯萃取部位中分离得到1对新的四氢呋喃型木脂素苷类化合物(1a和1b)和已知化合物肉果草苷(2)。结论化合物1a和1b为新化合物,是1对能发生差向异构的、不可分的化合物,分别命名为肉果草苷A(1a)、肉果草苷B(1b),且具有抗炎活性。Objective To study the chemical constituents of Lancea tibetica.Methods The chemical constituents were isolated and purified by silica gel,Sephadex LH-20 column chromatography and preparative RP-HPLC.Their structures were elucidated by analysis of NMR and HR-ESI-MS spectroscopic data.Zebrafish model was used to evaluate the anti-inflammatory activity of compounds.Results A pair of new tetrahydrofuran-type lignan glycosides(1a and 1b)and a known compound(tibeticoside)were isolated from the EtOAc-soluble partition of the aqueous ethanolic extract of L.tibetica.Conclusion Compounds 1a and 1b are new compounds,a pair of epimeric and indivisible compounds,named(7R,8R,8′S,9′S)-9′-hydroxyl tibeticoside and(7R,8R,8′S,9′R)-9′-hydroxyl tibeticoside,respectively.And compound 1 shows anti-inflammation activity.

关 键 词：肉果草 四氢呋喃型木脂素 肉果草苷A 肉果草苷B 抗炎 

分 类 号：R284.1[医药卫生—中药学]