中药引药上行的作用机制及其脑靶向制剂研究进展  

Research progress on mechanism of uplink of traditional Chinese medicine and its brain targeting preparations

作　　者：方亮 陶文康 程红艳 李大伟 王一帆 徐安琪 张彩云 FANG Liang;TAO Wen-kang;CHENG Hong-yan;LI Da-wei;WANG Yi-fan;XU An-qi;ZHANG Cai-yun(Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application,School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;Engineering Technology Research Center of Modernized Pharmaceutics,Anhui Education Department(AUCM),Hefei 230012,China;Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center,Hefei 230012,China;Institute of Pharmaceutics,Anhui Academy of Chinese Medicine,Hefei 230012,China;Anhui Key Laboratory of Compound Chinese Materia Medica,Hefei 230012,China)

机构地区：[1]安徽中医药大学药学院,药物制剂技术与应用安徽省重点实验室,安徽合肥230012 [2]安徽省教育厅现代药物制剂工程技术研究中心,安徽合肥230012 [3]安徽省道地中药材品质提升创新协同中心,安徽合肥230012 [4]安徽省中医药科学院药物制剂研究所,安徽合肥230012 [5]中药复方安徽省重点实验室,安徽合肥230012

出　　处：《中草药》2023年第10期3312-3321,共10页Chinese Traditional and Herbal Drugs

基　　金：安徽省科技重大专项项目(202203a07020031);安徽省教育厅基金项目(KJ2021ZD0065)。

摘　　要：引经药是在中药归经理论指导下,引导诸药直达病所,起“向导”作用的药物。冰片、石菖蒲、麝香、苏合香和安息香等芳香开窍类中药具有引药上行之功,可以改善血脑屏障的通透性,并通过引药上行作用促进其他药物透过血脑屏障,提高其他药物的生物利用度和脑组织分布。通过对近年来冰片、石菖蒲等引经药调节血脑屏障通透性及作用机制,芳香开窍类引经药与现代制剂结合构建新型脑靶向递药系统的研究进行综述,以期丰富引经药的科学内涵并为新型脑靶向药物递送系统的设计提供新策略。Under the guidance of theory of traditional Chinese medicine to return to the meridian,the drugs that introduce meridian are the drugs that guide all kinds of drugs to place of disease.Bingpian(Borneolum Syntheticum),Shichangpu(Acori Tatarinowii Rhizoma),Shexiang(Moschus),Suhexiang(Styrax),Anxixiang(Benzoinum)and other aromatic herbal medicines have the function of upward priming,which can improve permeability of blood-brain barrier,promote other drugs to penetrate blood-brain barrier through upward priming,and improve bioavailability of other drugs and brain tissue distribution.In this paper,the recent studies on regulation of blood-brain barrier permeability and its mechanism of action by borneol,calamus and other meridian induction drugs,and the construction of a new type of brain targeted drug delivery system by combining aromatically-induced meridian induction drugs with modern preparations were reviewed to enrich the scientific connotation of meridian induction drugs and provide a new strategy for the design of a new type of brain targeted drug delivery system.

关 键 词：引经药 引药上行 血脑屏障 脑靶向给药系统 冰片 石菖蒲 麝香 

分 类 号：R283[医药卫生—中药学]