从血论治肝纤维化经方的现代药理作用研究进展  

Research progress on modern pharmacological effects of classical prescriptions on treating liver fibrosis from blood

作　　者：贾可欣 李依洁 曲姣蓉 刘闰平 刘佳 王磊 李晓骄阳 JIA Ke-xin;LI Yi-jie;QU jiao-rong;LIU Run-ping;LIU Jia;WANG Lei;LI Xiao-jiaoyang(School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学生命科学学院,北京100029 [2]北京中医药大学中药学院,北京100029

出　　处：《中草药》2023年第10期3322-3328,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82004045);北京市自然科学基金资助项目(7212174)。

摘　　要：肝纤维化是一种肝脏损伤后可逆的持续性创伤修复反应。中医认为,正虚血瘀为肝纤维化疾病的核心病机,从血治肝是肝纤维化中医诊疗理念中特色鲜明的重要组成部分,但目前尚缺乏对从血治肝传统理论依据及现代研究进展的系统阐述。因此,阐明从血论治肝纤维化的中医诊疗理念,并对关联经方的现代药理研究进展进行总结,从而阐明从血治肝缓解肝纤维化进程的中医理论基础和现代科学内涵,为临床防治肝纤维化提供中医特色治疗思路和方法。Hepatic fibrosis is a reversible and sustained wound repair reaction after liver injury.In the basic theory of traditional Chinese medicine(TCM),the“weakened body resistance and blood stasis”is believed to become the center pathomechanism of liver fibrosis,and“ameliorating liver fibrosis by regulating blood”was also a distinctive significant part of the concept in clinical TCM diagnosis and treatment.However,the systematic review of TCM theory basis and research progress about ameliorating liver fibrosis by regulating blood is still missing.The TCM therapy of nourishing and(or)invigorating blood against liver fibrosis was clarified and the pharmacological mechanism of corresponding classic prescriptions was summarized.This review contributes to discovering the new classic prescriptions with potential anti-fibrotic efficacy,in turn expanding clinical treatment options for liver fibrosis.

关 键 词：肝纤维化 从血治肝 经方 补气生血 滋阴养血 养血活血 活血化瘀 散结消癥 

分 类 号：R285[医药卫生—中药学]