中药天然产物治疗炎症性肠病的研究进展  

Research progress on natural products from traditional Chinese medicine in treatment of inflammatory bowel disease

作　　者：孟欢 侯晓婷 张华敏 王旭德 MENG Huan;HOU Xiao-ting;ZHANG Hua-min;WANG Xu-de(Dalian Key Laboratory of Chronic Disease Research Center,Dalian University,Dalian 116622,China;College of Pharmacy,Yanbian University,Yanbian 133002,China)

机构地区：[1]大连大学慢性病研究中心大连市重点实验室,辽宁大连116622 [2]延边大学药学院,吉林延边133002

出　　处：《中草药》2023年第10期3349-3369,共21页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(61671098);韩国食品研究项目(2017029)。

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)是原因尚不明确的非特异性的肠道炎症性疾病。遗传、环境因素、免疫功能障碍、肠道菌群失调及肠道屏障功能受损都是其发生和发展的主要原因。临床上常用的治疗药物有氨基水杨酸类、抗生素类、皮质类固醇类等,但治愈率较低且不良反应明显。研究表明,中药天然产物具有免疫调节、调节肠道菌群组成和改善肠黏膜屏障功能等作用,可以有效治疗IBD。通过对常见的中药天然产物治疗IBD的研究进展进行综述,为中药天然产物的进一步开发及IBD的治疗提供一定的理论指导。Inflammatory bowel disease(IBD)is a non-specific intestinal inflammatory disease with unclear causes.It is thought that genetic elements,environmental elements,immune dysfunction,imbalance of intestinal flora and impairment of intestinal mucosal barrier function are the primary causes for the occurrence and development of IBD.The frequently used therapeutic drugs in clinic contain aminosalicylic acids(ASA),antibiotics and corticosteroids,yet the curative ratio is inferior and the side effects are obvious.New research suggests that the active constituents of traditional Chinese medicine(TCM)have the impact on such as adjusting immune function,ameliorating the composition of intestinal flora and promoting the function of intestinal mucosal barrier.Therefore,it can be used to treat IBD effectively.This article summarizes application and research advance about common natural products extracted from TCM in the treatment or prevention of IBD,mainly containing alkaloids,polyphenols,flavonoids,terpenoids,quinones,saponins and polysaccharides,which may contribute to comprehending more about their action mechanism for natural products of TCM in improving IBD,offering some theoretical guidance for the further development of natural products of TCM and the therapy of IBD.

关 键 词：炎症性肠病 中药天然产物 免疫调节 肠道菌群 肠黏膜屏障功能 小檗碱 姜黄素 黄芩苷 芍药苷 大黄酸 人参皂苷 黄芪多糖 

分 类 号：R285[医药卫生—中药学]