红芪多糖药理作用及机制的研究进展  

Research progress on pharmacological action and mechanism of Hedysarum polybotrys polysaccharides

作　　者：魏小成 李成义[1] 贾妙婷 罗旭东[1] 梁婷婷 刘书斌[1] 王燕[1] 强正泽[1] 王明伟[1] WEI Xiao-cheng;LI Cheng-yi;JIA Miao-ting;LUO Xu-dong;LIANG Ting-ting;LIU Shu-bin;WANG Yan;QIANG Zheng-ze;WANG Ming-wei(Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000

出　　处：《中草药》2023年第9期2953-2961,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81860683);国家自然科学基金资助项目(82160730);国家自然科学基金青年科学基金项目(82104345);甘肃省教育厅双一流重大科研项目(GSSYLXM-05);甘肃省科技计划项目(21YF5FA133)。

摘　　要：红芪是甘肃道地药材,现代药学研究表明红芪多糖是红芪的主要活性成分,是由五碳糖、六碳糖和其衍生物糖醇或糖酸构成的植物多糖,具有免疫调节、抗氧化、抗炎、抗肿瘤、机体保护、防治糖尿病及抗骨质疏松等药理作用。通过对红芪多糖的药理作用进行综述,阐明红芪多糖药理作用可能的机制,为红芪多糖的进一步研究及临床应用提供理论依据。Hongqi(Hedysari Radix)is a genuine herbal medicine in Gansu Province,Modern pharmaceutical studies have shown that Hedysarum polybotrys polysaccharides(HPS)are the main active components of Hedysari Radix,which is a plant polysaccharide composed of five carbon sugars,six carbon sugars and their derivatives,sugar alcohols or acids.It has pharmacological effects such as immune regulation,anti-oxidation,anti-inflammatory,anti-tumor,body protection,prevention and treatment of diabetes and antiosteoporosis.By summarizing the relevant literature of HPS,the pharmacological effects of HPS were reviewed to clarify the possible mechanism of pharmacological action of HPS.It is expected to provide theoretical basis and reference for further research and clinical application of HPS in various aspects.

关 键 词：红芪多糖 免疫调节 抗氧化 抗肿瘤 机体保护 防治糖尿病 

分 类 号：R285[医药卫生—中药学]