青钱柳化学成分及抗代谢性疾病药理作用研究进展  

Research progress on chemical constituents and anti-metabolic disease pharmacological effects of Cyclocarya paliurus

作　　者：徐若宸 张鹏[2,3] 向明 XU Ruo-chen;ZHANG Peng;XIANG Ming(Department of Biopharmacology,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430000,China;Department of Traditional Chinese Medicine and Natural Medicine,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430000,China;Hubei Key Laboratory of Natural Medical Chemistry and Resource Evaluation,Wuhan 430000,China)

机构地区：[1]华中科技大学同济医学院药学院生物药学系,湖北武汉430000 [2]华中科技大学同济医学院药学院中药与天然药物学系,湖北武汉430000 [3]湖北省天然药物化学与资源评价重点实验室,湖北武汉430000

出　　处：《中草药》2023年第9期2962-2977,共16页Chinese Traditional and Herbal Drugs

基　　金：2022年湖北省科技计划项目(2022BEC052)。

摘　　要：青钱柳Cyclocarya paliurus为胡桃科青钱柳属植物,具有生津解渴、降压强心等功效。代谢性疾病包括糖尿病、高脂血、高血压、高尿酸和肝病在内的代谢紊乱性疾病,是全球亚健康状态的主要原因。青钱柳含有丰富的三萜、黄酮及多糖等活性成分,具有降血糖、调血脂、降血压、降尿酸和肝脏保护等多种药理活性,对代谢性疾病有一定的改善作用。通过对青钱柳的化学成分和抗代谢性疾病的药理作用进行综述,为该资源后续的研究、开发与利用提供参考。Qingqianliu(Cyclocarya paliurus)belongs to the genus Cyclocarya in Juglandaceae family,with the function of engendering liquid and quenching thirst,lowering blood pressure and strengthening heart.Metabolic diseases are recognized as a group of diseases characterized by metabolic disorder,including diabetes,hyperlipidemia,hypertension,high uric acid and liver disease,and are the main cause of sub-health conditions worldwide.Cyclocarya paliurus is rich in active ingradients such as triterpenes,flavonoids and polysaccharides,and has hypoglycemia,hypolipidemic,antihypertensive,anti-uric acid,liver protection and other effects.This article reviews the chemical composition and pharmacological effects of Cyclocarya paliurus against metabolic diseases,in order to provide reference for the subsequent research,development and utilization of this resource.

关 键 词：青钱柳 三萜 黄酮 糖尿病 高血脂 

分 类 号：R285[医药卫生—中药学]