通脉养心方及其化学成分治疗心肌缺血/再灌注损伤的作用机制研究进展  

Research progress on mechanism of Tongmai Yangxin Recipe and its chemical components in treatment of myocardial ischemia/reperfusion injury

作　　者：王旭 于鲁 李珠 何媛媛 高杉[1] 李琳[1] 于春泉[1] WANG Xu;YU Lu;LI Zhu;HE Yuan-yuan;GAO Shan;LI Lin;YU Chun-quan(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,天津301617

出　　处：《中草药》2023年第9期3012-3021,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82104565)。

摘　　要：心肌缺血/再灌注损伤(myocardial ischemia/reperfusion injury,MI/RI)是急性心肌梗死患者术后预后不良的关键问题。通脉养心方具有益气养阴和通脉止痛的功效,含有黄酮类、木脂素类和皂苷类等化学成分,其药理作用各有侧重,尤其是具有雌激素活性的化学物质在治疗MI/RI方面的作用日益显现。通脉养心方及其化学成分具有调节线粒体途径、抑制炎症反应、改善血管内皮功能和抑制钙离子超载等作用,有着良好的应用潜力。近年来,关于通脉养心方治疗心血管疾病的临床研究也逐渐增多,且临床效果显著。从该方的化学成分、作用机制和临床应用等方面对其治疗MI/RI进行整理和分析,为其进一步开发和治疗心血管疾病提供参考。Myocardial ischemia/reperfusion injury(MI/RI)is the key problem of poor prognosis in patients with acute myocardial infarction after operation.Tongmai Yangxin Recipe(通脉养心方)has the effects of invigorating qi,nourishing yin,dredging collaterals and relieving pain,and contains flavonoids,lignans,saponins and other chemical components.Its pharmacological effects are different,especially the effect of estrogenic chemicals in the treatment of MI/RI is increasingly apparent.Many studies have shown that this recipe and its chemical components have the functions of regulating mitochondrial pathway,inhibiting inflammatory reaction,improving vascular endothelial function and inhibiting calcium overload,and have good application potential.In recent years,the clinical application on treating cardiovascular diseases with Tongmai Yangxin Recipe has gradually increased,and the clinical effect is remarkable.In this paper,the chemical composition,mechanism of action and clinical research of this prescription will be sorted out and analyzed to provide reference for its further development and treatment of cardiovascular diseases.

关 键 词：心肌缺血/再灌注损伤 通脉养心方 心血管疾病 雌激素活性成分 抗炎 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]