受体活性调节蛋白的研究进展及其在疾病预防中的应用前景  

Research progress on receptor activity-modifying proteins and their application prospects in disease prevention

作　　者：钱蕊 王礼群(综述) 姚于勤 方爱平(审校)[1] QIAN Rui;WANG Liqun;YAO Yuqin;FANG Aiping(West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西公共卫生学院,华西第四医院,四川成都610041 [2]四川大学华西-协和陈志潜卫生健康研究院职业病防治研究中心,四川成都610041

出　　处：《中国生物制品学杂志》2023年第5期626-630,共5页Chinese Journal of Biologicals

基　　金：国家自然科学基金(81802801)。

摘　　要：受体活性调节蛋白(receptor activity-modifying proteins,RAMPs)是Ⅰ型跨膜蛋白,是多种G蛋白偶联受体(Gprotein-coupled receptors,GPCRs)的活性调节蛋白。RAMPs与神经系统疾病、心血管疾病、肾功能、骨骼发育、肥胖等生理病理现象有关,对疾病预防具有重要意义,是多种疾病治疗的潜在靶点,且与疾病预后也密切相关。目前对可能调控RAMPs表达的蛋白的研究较少,本文着重综述了可能对RAMP3转录表达具有调控作用的甾醇调节元素结合因子-2(sterol regulatory element-binding factor-2,SREBF-2),并对RAMPs在生物学、病理学和药理学方面的研究进展作一综述,为RAMPs的进一步研究及其相关疾病的预防和检测提供参考。Receptor activity-modifying proteins(RAMPs)are type I transmembrane proteins,which are activity-modifying proteins of a variety of G-protein-coupled receptors(GPCRs).RAMPs are related to physiological and pathological phenomena such as neurological diseases,cardiovascular diseases,renal function,skeletal development and obesity,and of great significance for disease prevention,which are potential targets for the treatment of various diseases and also closely related to the prognosis of diseases.At present,there are few studies on proteins that may regulate the expression of RAMPs.This paper focuses on the sterol regulatory element-binding factor-2(SREBF-2)that may regulate the transcription and expression of RAMP3,and reviews the research progress of RAMPs in biology,pathology and pharmacology,providing a reference for the further research on RAMPs and the prevention and detection of related diseases.

关 键 词：受体活性调节蛋白 G蛋白偶联受体 疾病预防 病理学 信号通路 

分 类 号：Q816[生物学—生物工程] R966[医药卫生—药理学]