外侧隔核的功能及其机制研究进展  

Recent advance on the functions and mechanisms of the lateral septum

作　　者：潘翔宇 周瑜 韦东方 董海龙 曹君利 Pan Xiangyu;Zhou Yu;Wei Dongfang;Dong Hailong;Cao Junli(Jiangsu Province Key Laboratory of Anesthesiology,Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technolo-gy,NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,Xuzhou Medical University,Xuzhou 221004,China;Department of Anesthesiology and Perioperative Medicine,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]徐州医科大学江苏省麻醉学重点实验室,江苏省麻醉与镇痛应用技术重点实验室,国家药品监督管理局麻醉精神药物研究与评价重点实验室,徐州221004 [2]空军军医大学西京医院麻醉与围术期医学科,西安710032

出　　处：《国际麻醉学与复苏杂志》2023年第5期544-551,共8页International Journal of Anesthesiology and Resuscitation

基　　金：科技创新2030“脑科学与类脑研究”重大项目(2021ZD0203100);江苏省研究生科研与实践创新计划(KYCX22_2920)。

摘　　要：外侧隔核(lateral septum,LS)位于胼胝体与内侧隔核(medial septum,MS)之间,主要由γ‑氨基丁酸(γ‑aminobutyric acid,GABA)能神经元组成。LS作为边缘系统的重要枢纽接受海马的传入,向下丘脑发出广泛的神经纤维投射,参与情绪、社会和动机等行为调控。文章围绕LS的解剖与功能异质性,系统综述了不同神经元亚型及其相关神经环路在焦虑、恐惧、运动、攻击、进食、记忆、睡眠和麻醉中的调控作用,以期为进一步认识LS的病理和生理功能提供参考。The lateral septum(LS)is located between the corpus callosum and medial septum(MS)and predominantly composed ofγ‑aminobutyric acid‑ergic neurons.The LS,a nexus of the limbic system,integrates hippocampus inputs,and projects abundant output connections to the hypothalamus to regulate variety of functions,including emotional,social,and motivational behavior.Emerging evidence suggests the neuroanatomical and functional heterogeneity of the LS.This article overviews diverse neuron subtypes and the regulatory effects of their neural circuit on anxiety,fear,movement,aggression,feeding,memory,sleep,and anesthesia.These mechanisms will provide reference for further understanding physiological and pathophysiological effects of the LS.

关 键 词：外侧隔核 神经环路 焦虑 攻击行为 进食 

分 类 号：R338[医药卫生—人体生理学]