致幻剂类药物的抗抑郁作用及其潜在机制研究进展  

Advances in the antidepressant actions and potential mechanisms of psychedelics

作　　者：刘德农 余志鹏 徐鹏 楼忠泽[3] 阮列敏[1] 沈昊伟 Liu Denong;Yu Zhipeng;Xu Peng;Lou Zhongze;Ruan Liemin;Shen Haowei(Department of Physiology and Pharmacology,Ningbo University School of Medicine,Ningbo 315211,China;Ministry of Public Security Drug Intelligence Center,Beijing 100080,China;Department of Psychosomatic Medicine,Ningbo First Hospital,Ningbo 315010,China)

机构地区：[1]宁波大学医学院生理与药理学系,宁波315211 [2]公安部禁毒情报技术中心,北京100080 [3]宁波市第一医院心身医学科,宁波315010

出　　处：《中华精神科杂志》2023年第3期199-204,共6页Chinese Journal of Psychiatry

基　　金：国家自然科学基金项目(31571094,32171017)。

摘　　要：抗抑郁药治疗抑郁症存在起效慢、缓解率低、不良反应多等不足之处。致幻剂是一种可以改变感知觉和情绪并影响认知的强效精神活性物质。越来越多的证据显示部分致幻剂类药物能够正向促进个体社会功能,对中重度抑郁症具有快速、持续的改善作用。因此,近年来致幻剂类药物的抗抑郁作用逐渐受到关注。本文对致幻剂中代表性药物的抗抑郁效果及其潜在作用机制的研究进展进行总结,并对致幻剂类药物的使用风险进行讨论。Major antidepressants for the treatment of depression have several shortcomings such as delayed therapeutic action,limited remission rate and various adverse effects.Psychedelics are a group of psychoactive substances that can improve perception,mood and cognition.An increasing body of evidence shows that psychedelics positively promote individual social functioning and have a rapid and sustained improvement in moderate or severe depression.Therefore,the antidepressant effects of psychedelics have gained increasing attentions in recent years.This review summarizes the progress of research on the antidepressant effects of some representative psychedelics and their potential mechanisms of antidepressant action,and discusses the risks of clinical application of psychedelics.

关 键 词：致幻药 抑郁症 受体 血清素 5-HT_(2A) 

分 类 号：R971.4[医药卫生—药品]