抗精神病药低剂量联合应用引起恶性综合征1例  

A case of neuroleptic malignant syndrome caused by low-dose combination of multiple antipsychotics

作　　者：卢盼盼 司天梅[1] 蒲城城[1] Lu Panpan;Si Tianmei;Pu Chengcheng(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100191,China)

机构地区：[1]北京大学第六医院、北京大学精神卫生研究所、国家卫生健康委员会精神卫生学重点实验室(北京大学)、国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100191

出　　处：《中华精神科杂志》2023年第3期232-235,共4页Chinese Journal of Psychiatry

摘　　要：恶性综合征(neuroleptic malignant syndrome,NMS)是一种罕见、严重、致死率较高的抗精神病药不良反应。本文通过报告1例患有心境障碍的青年女性患者联合应用抗精神病药引发NMS个案,来提示临床医生多种抗精神病药联用的治疗策略,即使小剂量,也存在NMS风险,并结合文献对NMS的危险因素、临床表现、治疗要点进行讨论,以提示临床医生应重视NMS的预防、早期识别及干预。Neuroleptic malignant syndrome(NMS)is a rare,serious,and fatal adverse reaction to antipsychotics.This article reports a case of NMS caused by the concomitant use of multiple antipsychotics in a young female patient with mood disorders.This case reminds clinicians of the risk of NMS when multiple antipsychotics are given simultaneously,even in small doses.This article also discusses the risk factors,clinical manifestations,and treatment strategies of NMS,to suggest that clinicians should pay attention to the prevention,early recognition and intervention of NMS.

关 键 词：安定药恶性综合征 电惊厥疗法 抗精神病药多药联用疗法 

分 类 号：R969.3[医药卫生—药理学]