仙灵骨葆胶囊肝毒性研究进展  

Overview of hepatotoxicity of Xianling Gubao capsules

作　　者：朱春雾 余雪君[1] 孙鑫 刘成海 ZHU Chunwu;YU Xuejun;SUN Xin;LIU Chenghai(Department of Gerontology,Putuo Hospital affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Institute of Liver Diseases,Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai 201203,China;Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属普陀医院老年科,上海200062 [2]上海中医药大学附属曙光医院肝病研究所,上海201203 [3]上海市中医临床重点实验室,上海201203 [4]肝肾疾病病证教育部重点实验室,上海201203

出　　处：《中国药物警戒》2023年第5期496-499,共4页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(81730109,82274305);上海市中医药事业发展三年行动计划[ZY(2018-2020)-CCCX-5001];上海市科学技术委员会科技计划项目(20Z21900100);上海市临床重点专科建设项目(shslczdzk01201)。

摘　　要：目的分析仙灵骨葆胶囊的肝毒性,为其安全合理使用提供参考。方法通过查阅1994年1月1日至2022年8月31日国内外相关文献,从肝毒性表现、肝损伤的因素、毒性机制、减毒应对措施等方面对仙灵骨葆胶囊肝毒性研究概况进行整理和总结。结果仙灵骨葆胶囊的毒性成分主要是补骨脂和淫羊藿,与患者性别、年龄、药量等因素有关。结论临床使用中应加强仙灵骨葆胶囊肝毒性的监测,以减少肝损伤的发生。Objective To analyze the hepatotoxicity of Xianling Gubao capsules and provide reference for its safe and reasonable use.Methods By referring to the relevant literature at home and abroad from January 1994 to August 2022,the research situation of liver toxicity of Xianling Gubao capsules from the aspects of liver toxicity,cause of liver injury,toxicity mechanism and attenuated countermeasures was summarized.Results The toxic components of Xianling Gubao capsules are mainly Psoraleae Fructus and Epimedii Folium,which are related to factors such as patient’s gender,age and dosage.Conclusion The monitoring of hepatotoxicity of Xianling Gubao capsules should be strengthened in clinical use to reduce the occurrence of liver injury.

关 键 词：仙灵骨葆 胶囊 肝毒性 药品不良反应 肝损伤 补骨脂 淫羊藿 

分 类 号：R977[医药卫生—药品] R994.11[医药卫生—药学]