醋酸泼尼松与塞来昔布治疗亚急性甲状腺炎对氧化抗氧化系统和Fas/Fasl表达的影响  

Effects of Prednisone acetate and celecoxib on oxidative antioxidant system and Fas/Fasl expression in subacute thyroiditis

作　　者：邢同凯 Xing Tongkai(First People's Hospital of Liangshan Prefecture,Xichang,Sichuan 615000,China)

机构地区：[1]四川省凉山州第一人民医院,四川西昌615000

出　　处：《首都食品与医药》2023年第11期54-56,共3页Capital Food Medicine

摘　　要：目的探究醋酸泼尼松与塞来昔布治疗亚急性甲状腺炎对氧化抗氧化系统和Fas/Fasl表达的影响.方法采取随机数字表法将四川省凉山州第一人民医院自2020年3月-2022年1月收治的亚急性甲状腺炎患者90例分为醋酸泼尼松组与塞来昔布组,每组45例,对比两组疗效、治疗前后甲状腺功能指标、氧化抗氧化系统和Fas/Fasl表达水平,同时观察治疗期间不良反应.结果醋酸泼尼松组与塞来昔布组相比,前者临床总有效率较高;治疗后,醋酸泼尼松组与塞来昔布组相比,TSH、FT3较高,FT4较低,TPOAb、TGAb、MDA值均较低,Fas及Fasl值较低,差异有统计学意义(P<0.05).两组治疗期间不良反应相比,差异无统计学意义(P>0.05).结论醋酸泼尼松与塞来昔布相比,治疗亚急性甲状腺炎获得了更好的效果,可改善甲状腺功能指标,对氧化抗氧化系统和Fas/Fasl的表达起到了改善作用,同时也避免了不良反应增加.Objective To investigate and analyze the effects of prednisone acetate and celecoxib on oxidative antioxidant system and Fas/Fasl expression in the treatment of subacute thyroiditisM.ethods 90 cases of subacute thyroiditis admitted to our hospital fromM arch 2020 to January 2022 were divided into prednisone acetate group and Cincloxib group,45 cases in each group by random numbera tble method.The efficacy,thyroid function indexes,antioxidant sytsem and Fas/Fasl expression levels of the two groups were compraed before and after treatment,and adverse reactions during treatment weer observed.Results The total effective rate of prednisone acetate group was higher than that of celeoxib group;compared with crecoxibg roup,prednisone acetate group after treatment had higher TSH h,igher FT3 and lower FT4,lower TPOAb,TGAb and MDA values,and lowerF as and Fasl values,the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups during treatment P(>0.05).Conclusions Prednisone acetate is more effective than celeroxib in the treatment of subacute thyroiditis.It can promote the improvement of thyroid function indexes,improve the antioxidant system and Fas/Fasl expression,and avoid the increase of adverse reactions.

关 键 词：醋酸泼尼松 塞来昔布 亚急性甲状腺炎 氧化抗氧化系统 FAS/FASL 

分 类 号：R581[医药卫生—内分泌]