慢性阻塞性肺疾病合并2型糖尿病患者急性发作期不同血糖控制水平对肺功能和住院天数的影响  

Effect of different blood glucose level on pulmonary function and length of hospital stay in patients with chronic obstructive pulmonary disease complicated with type 2 diabetes mellitus

作　　者：郑红艳 王志刚 ZHENG Hongyan;WANG Zhigang(Department of Respiratory Medicine,People's Hospital Affiliated of Quanzhou Medical College,Fujian Province,Quanzhou 362000,China)

机构地区：[1]泉州医学高等专科学校附属人民医院呼吸内科,福建泉州362000

出　　处：《中国当代医药》2023年第16期49-53,共5页China Modern Medicine

基　　金：福建省泉州市科技计划项目(2018N124S)。

摘　　要：目的对于慢性阻塞性肺疾病(COPD)合并2型糖尿病患者(T2DM)急性发作期采取不同血糖控制水平对肺通气功能、弥散功能和住院天数的影响。方法选取2020年6月至2021年9月泉州医学高等专科学校附属人民医院呼吸内科收治的85例处于急性发作期的COPD合并T2DM住院患者,采用随机数字表法分为观察组43例和对照组42例。观察组血糖控制目标:空腹血糖<6.1 mmol/L且餐后2 h血糖<8 mmol/L,治疗采用COPD常规治疗和强化降糖方法。对照组血糖控制的目标:全天空腹及餐后2 h血糖都<11.1 mmol/L,治疗采用COPD常规治疗和基础降糖方法。比较两组住院期间的空腹、餐后血糖水平和肺功能,并统计住院天数。结果观察组的最大呼气中期流量(MMEF)水平、第1秒用力呼气量(FEV_(1))水平、第1秒用力呼气量占用力肺活量的百分比(FEV_(1)/FVC)、一氧化碳弥散量(DLCO)均高于对照组,差异有统计学意义(P<0.05)。观察组平均住院天数短于对照组,差异有统计学意义(P<0.05)。结论COPD合并T2DM患者急性发作期,高于正常范围的血糖水平不利于肺通气功能和弥散功能的改善,严格控制血糖至正常水平能缩短病程,并延缓其肺功能减退的进程。Objective To analyze the effect of different blood glucose level on pulmonary function and length of hospital stay in patients with chronic obstructive pulmonary disease complicated(COPD)with type 2 diabetes mellitus(T2DM)during the acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 85 AECOPD patients hospitalized in Department of Respiratory Medicine,People's Hospital Affiliated of Quanzhou Medical College from June 2020 to September 2021 were chosen as the research objects.According to the method of random number table,they were divided into observation group(43 cases)and control group(42 cases).Blood glucose control target of observation group was that fasting blood glucose was less than 6.1 mmol/L and postprandial blood glucose was less than 8 mmol/L.Observation group was treated with conventional therapy of COPD and strengthen hypoglycemic method.Blood glucose control target of control group was that fasting and postprandial blood glucose throughout the day were less than 11.1 mmol/L.Control group was treated with conventional therapy of COPD and basic hypoglycemic method.Fasting blood glucose level,postprandial blood glucose level and pulmonary function during hospitalization were compared between the two groups.Length of hospital stay was counted.Results In the observation group,the level of maximal mid-expiratory flow,the level of forced expiratory volume in the first second,the ratio of forced expiratory volume in one second to forced vital capacity,the level of carbon monoxide diffusion capacity were higher than those in the control group,with statistical significances(P<0.05).Average hospital stay in observation group was shorter than that in the control group,with statistical significance(P<0.05).Conclusion During AECOPD,blood glucose level above the normal range is disadvantageous in the improvement of ventilation function and diffusion function in patients with COPD complicated with T2DM.Keeping blood glucose level in the normal range in AECOPD can shorten the pat

关 键 词：慢性阻塞性肺疾病 2型糖尿病 血糖 肺功能 住院天数 

分 类 号：R563[医药卫生—呼吸系统]