王阶治疗冠心病用药规律研究  

Wang Jie′s Rule of Drug Use in Treating Coronary Heart Disease

作　　者：刘金垒 惠小珊 程诺 李兴业 张振鹏[1] 王阶[1] LIU Jinlei;HUI Xiaoshan;CHENG Nuo;LI Xingye;ZHANG Zhenpeng;WANG Jie(Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing China 100053;Graduate School,Beijing University of Chinese Medicine,Beijing China 100029)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学研究生院,北京100029

出　　处：《中医学报》2023年第7期1512-1518,共7页Acta Chinese Medicine

基　　金：国家自然科学基金重点项目(82230124);国家自然科学基金面上项目(81974556);中医药传承与创新“百千万”人才工程项目(岐黄首席科学家)(020100040102)。

摘　　要：目的:对全国名中医王阶教授治疗冠状动脉粥样硬化性心脏病(简称“冠心病”)的医案进行数据挖掘与分析,以系统总结王阶教授用药经验和规律。方法:在收集和整理王阶教授治疗冠心病的临床医案的基础上,建立医案数据集。运用处方中药频次分析、中药共现网络分析、用药功效分析、聚类分析、关联规则分析等方法,对医案进行定性和定量分析。结果:共筛选纳入王阶教授治疗冠心病医案398条,结果显示,王阶教授治疗冠心病常用中药196味,其中高频中药有黄芪、肉苁蓉、甘草、巴戟天、半夏、川芎、党参、丹参、瓜蒌、薤白、赤芍等,处方中共同出现的高频中药有肉苁蓉、黄芪、甘草、巴戟天、党参、丹参、川芎、半夏、瓜蒌、薤白等,常用中药的功效最多的是补虚药,其次是活血化瘀药,常用中药聚类结果有“茯苓、白术、柴胡、当归、陈皮、升麻”等,常用中药配伍为薤白-半夏-瓜蒌,巴戟天-甘草-黄芪-肉苁蓉等。结论:王阶教授善于运用补虚药和活血化瘀药调治冠心病,补中益气汤加减、冠心2号方加减、瓜蒌薤白半夏汤加减和桂枝加龙骨牡蛎汤加减等都是王阶教授的常用加减方。常用的药对配伍有神曲-山楂化浊降脂消除血管斑块以及独活-桑寄生等祛风湿药发挥特色的疗效。Objective:to conduct data mining and analysis on the medical records of Professor Wang Jie in the treatment of coronary atherosclerotic heart disease(CHD),so as to systematically summarize the experience and rules of medication in traditional Chinese medicine.Methods:On the basis of collecting and sorting out the clinical records of Professor Wang Jie in the treatment of coronary heart disease,the data set of medical records was established.The methods of prescription traditional Chinese medicine frequency analysis,traditional Chinese medicine co-occurrence network analysis,drug efficacy analysis,cluster analysis and association rule analysis were used to qualitatively and quantitatively analyze the medical records.Results:A total of 398 medical records of Professor Wang Jie in treatment of coronary heart disease were selected.the results suggested that there were 196 traditional Chinese medicines commonly used by Professor Wang Jie in treatment of coronary heart disease.Among them,high-frequency traditional Chinese medicines are Huangqi(radix astragali),Roucongrong(cistanche deserticola),Gancao(glycyrrhiza uralensis),Bajitian(morinda officinalis),Banxia(pinellia ternata),Chuanxiong(ligusticum wallichii),Dangshen(codonopsis pilosula),Danshen(salvia miltiorrhiza),Gualou(trichosanthes),Xiebai(allium macrostemon),Chishao(radix paeoniae rubra),and so on,all of which except Chishao are high-frequency drugs used in the same prescription.The most commonly used traditional Chinese medicine is the medicine for tonifying deficiency,followed by promoting blood circulation and removing blood stasis,and the clustering result of commonly used traditional Chinese medicines are Fuling(poria cocos),Baizhu(rhizoma atractylodis),Chaihu(radix bupleuri),Danggui(angelica sinensis),Chenpi(pericarpium citri reticulatae)and Shengma(rhizoma cimicifugae).The commonly used TCM grouped drugs are Xiebai-Banxia-Gualou(allium macrostemon-pinellia ternata-trichosanthes)and Bajitian-Gancao-Huangqi-Roucongrong(morinda officinalis-glycyrrhiza urale

关 键 词：冠状动脉粥样硬化性心脏病 补虚药 活血化瘀药 用药规律 数据挖掘 王阶 冠心2号方 

分 类 号：R249.27[医药卫生—中医临床基础]