乙酰半胱氨酸与氨溴索雾化吸入治疗小儿支气管肺炎的临床效果比较  

Comparison of the clinical effects of acetylcysteine and ambroxol atomization inhalation in the treatment of bronchopneumonia in children

作　　者：孟姣 马甜 陈海英 思希尧 呼在平 MENG Jiao;MA Tian;CHEN Haiying;SI Xiyao;HU Zaiping(Yulin Children's Hospital/the People's Hospital of Yuyang District,Yulin 719000,China)

机构地区：[1]榆林市儿童医院/榆阳区人民医院,陕西榆林719000

出　　处：《临床医学研究与实践》2023年第17期57-60,共4页Clinical Research and Practice

摘　　要：目的 比较乙酰半胱氨酸与氨溴索雾化吸入治疗小儿支气管肺炎的临床效果。方法 选取2020年9月至2021年9月我院收治的88例支气管肺炎患儿为研究对象,将其随机分为对照组(44例,常规治疗联合氨溴索雾化吸入)与观察组(44例,常规治疗联合乙酰半胱氨酸雾化吸入)。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的痰液黏稠度情况优于对照组(P<0.05)。治疗后,观察组的C反应蛋白(CRP)、转化生长因子-β_(1)(TGF-β_(1))水平低于对照组(P<0.05)。治疗后,观察组的第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)及第1秒钟用力肺活量占预计值百分比(FEV_(1)%)高于对照组(P<0.05)。两组的药物不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 乙酰半胱氨酸治疗小儿支气管肺炎较氨溴索效果显著,可显著降低患儿的痰液黏稠度,缓解其炎症反应及咳嗽症状,提高肺功能,值得临床推广与应用。Objective To compare the clinical effect of acetylcysteine and ambroxol atomization inhalation in the treatment of bronchopneumonia in children.Methods A total of 88 children with bronchopneumonia admitted in our hospital from September 2020 to September 2021 were randomly divided into control group(44 cases,routine treatment combined with ambroxol atomization inhalation)and observation group(44 cases,routine treatment combined with acetylcysteine atomization inhalation).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the sputum viscosity of the observation group was better than that of the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP)and transforming growth factor-β_(1)(TGF-β_(1))in the observation group were lower than those in the control group(P<0.05).After treatment,the forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)and the first second forced vital capacity percentage of expected value(FEV_(1)%)in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Acetylcysteine is more effective than ambroxol in the treatment of bronchopneumonia in children.It can significantly reduce the sputum viscosity of children,relieve their inflammatory response and cough symptoms,and improve lung function.It is worthy of clinical promotion and application.

关 键 词：乙酰半胱氨酸 氨溴索 雾化吸入 小儿支气管肺炎 痰液黏稠度 炎症反应 

分 类 号：R563.1[医药卫生—呼吸系统]