2型糖尿病患者血清肿瘤标志物CA19-9、CEA水平与糖化血红蛋白、血糖、C肽、脂类等指标的相关性研究  

Study on the Correlation between Serum Tumor Markers CA19-9,CEA and Glycosylated Hemoglobin,Blood Glucose,C-peptide,Lipids and Other Indicators in Patients with Type 2 Diabetes

作　　者：梁碧 陈月云 蔡月娣 覃东红[1] 缪媛媛 LIANG Bi;CHEN Yueyun;CAI Yuedi;QIN Donghong;MIAO Yuanyuan(Department of Endocrinology,Agricultural Reclamation Central Hospital,Zhanjiang,Guangdong Province,524000 China;Internal Medicine,Zhanjiang Mazhang Huiwen Hospital,Zhanjiang,Guangdong Province,524000 China)

机构地区：[1]广东省农垦中心医院内分泌科,广东湛江524000 [2]湛江麻章辉文医院内科,广东湛江524000

出　　处：《糖尿病新世界》2023年第4期17-20,共4页Diabetes New World Magazine

基　　金：2021年湛江市科技计划项目(2021B01256)。

摘　　要：目的2型糖尿病患者血清肿瘤标志物CA19-9、CEA水平与糖化血红蛋白、血糖、C肽、脂类等指标的相关性探讨。方法将2020年7月—2022年8月广东省农垦中心医院接诊的300例2型糖尿病患者纳入研究组,选取同期参与健康体检的300名健康人纳入对照组,分析血清肿瘤标志物CA19-9、CEA水平与糖化血红蛋白、血糖、C肽、脂类等指标的相关性。结果研究组患者的CA19-9、CEA、HbA1c、FPG、TG指标高于对照组,HDL指标低于对照组,差异有统计学意义(P<0.05)。两组TC与LDL指标对比,差异无统计学意义(P>0.05)。血清肿瘤标志物与糖脂代谢指标相关性分析显示,HbA1c、FPG、2 hPG与CA19-9及CEA呈正相关(P<0.05),C_(0)、C_(2)与CEA呈负相关(P<0.05)。结论2型糖尿病患者血清肿瘤标志物CA19-9、CEA水平比健康者更高,且与HbA1c、血糖及C肽有一定相关性。Objective To explore the correlation between serum tumor markers CA19-9,CEA and glycosylated hemoglobin,blood glucose,C-peptide,lipids and other indicators in patients with type 2 diabetes.Methods 300 patients with type 2 diabetes who were admitted to Guangdong Provincial Agricultural Reclamation Center Hospital from July 2020 to August 2022 were included in the study group,and 300 healthy people who participated in health examination at the same time were selected as the control group.To analyze the correlation between serum tumor markers CA19-9 and CEA levels and indicators such as glycosylated hemoglobin,blood sugar,C-peptide,and lipids.Results The CA19-9,CEA,HbA1c,FPG,and TG indexes of patients in the study group were higher than those in the control group,while the HDL indexes were lower than those in the control group,and the difference was statistically significant(P<0.05)There was no statistically significant difference in TC and LDL between the two groups(P>0.05).The correlation analysis between serum tumor markers and glycolipid metabolism indicators showed that HbA1c,FPG,and 2 hPG were positively correlated with CA19-9 and CEA(P<0.05),C_(0)and C_(2)were negatively correlated with CEA(P<0.05).Conclusion The levels of serum tumor markers CA19-9 and CEA in patients with type 2 diabetes were higher than those in healthy people,and had some correlation with HbA1c,blood glucose and C-peptide.

关 键 词：2型糖尿病 血清肿瘤标志物 CA19-9 CEA 糖化血红蛋白 血糖 

分 类 号：R587.1[医药卫生—内分泌]