基于促代谢因子探讨卡格列净对2型糖尿病胰岛素抵抗的影响  

Study on the Effect of Cargligine on Insulin Resistance in Type 2 Diabetes Based on Pro Metabolic Factors

作　　者：张星锬 杨冰洲[1] 刘丰民[1] ZHANG Xingtan;YANG Bingzhou;LIU Fengmin(Department of Endocrinology,Fuzhou First Hospital,Fuzhou,Fujian Province,350001 China)

机构地区：[1]福州市第一医院内分泌科,福建福州350001

出　　处：《糖尿病新世界》2023年第4期77-80,共4页Diabetes New World Magazine

摘　　要：目的分析卡格列净在2型糖尿病患者临床治疗中的效果以及对患者促代谢因子以及胰岛素抵抗的影响。方法选取2020年4月—2022年1月福州市第一医院收治的140例2型糖尿病患者为研究对象,以随机数字表法分为两组,观察组患者(n=70)采取卡格列净联合二甲双胍治疗,对照组(n=70)单纯实施二甲双胍治疗,记录并比较两组患者促代谢因子指数、胰岛素抵抗指数以及血糖水平。结果治疗后,观察组空腹血糖与餐后2 h血糖水平显著低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组胰岛素抵抗指数显著低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组促代谢因子指数显著低于对照组,差异有统计学意义(P<0.05)。结论在2型糖尿病患者临床治疗中,卡格列净有助于改善患者胰岛素抵抗以及促代谢因子指数。Objective To analyze the effect of canagliflozin in the clinical treatment of type 2 diabetes mellitus patients and its effect on the indexes of pro-metabolic factors and insulin resistance index of patients.Methods 140 patients with type 2 diabetes admitted to Fuzhou First Hospital from April 2020 to January 2022 were selected as the research objects,and they were divided into two groups by random number table,the patients in the observation group(n=70)were treated with canagliflozin combined with metformin,while the control group(n=70)was treated with metformin alone.Pro-metabolizing factor index,insulin resistance index,and blood glucose levels were recorded and compared between the two groups.Results After treatment,the fasting blood glucose level of the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).After treatment,the insulin resistance index in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the pro-metabolic factor index in the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of patients with type 2 diabetes,canagliflozin helps to improve patient insulin resistance as well as the prometabolic factor index.

关 键 词：2型糖尿病 促代谢因子指数 卡格列净 胰岛素抵抗 

分 类 号：R4[医药卫生—临床医学]