经络辨证塞鼻法对偏头痛急性发作患者即刻止痛疗效的随机对照试验  

Immediate Analgesic Effect of Nasal Plugging Method Based on Channel Pattern Differentiation in the Treatment of Acute Migraine Attack:A Randomized Controlled Trial

作　　者：王怡雯 刘娇娇 史华伟[1] 董兴鲁[1] 林丹 高金阳 崔方圆[1] WANG Yiwen;LIU Jiaojiao;SHI Huawei;DONG Xinglu;LIN Dan;GAO Jinyang;CUI Fangyuan(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,100700)

机构地区：[1]北京中医药大学东直门医院,100700

出　　处：《中医杂志》2023年第10期1022-1027,共6页Journal of Traditional Chinese Medicine

基　　金：北京中医药大学东直门医院2020年度科技创新专项(DZMKJCX-2020-061)。

摘　　要：目的 观察经络辨证塞鼻法对偏头痛急性发作的即刻止痛作用及安全性。方法 将186例偏头痛患者随机分为治疗组和对照组各93例,两组患者均按经络辨证法分别辨证为厥阴、少阳、太阳、阳明头痛。治疗组依经络辨证结果予相应经络塞鼻散0.2 g纳入鼻腔外鼻道处,持续15 min;对照组予布洛芬缓释胶囊0.3 g口服,两组均于急性发作时给药1次。观察两组患者治疗前及治疗后0.5 h、2 h的头痛视觉模拟评分(VAS),治疗前及治疗后0.5 h伴随症状积分,两组头痛缓解患者起效时间及24 h内复发率。结果 两组治疗后0.5 h、2 h时总体及各经络头痛VAS评分,治疗后0.5 h总体及少阳、太阳、阳明头痛伴随症状积分均较治疗前明显降低,两组治疗后2 h总体及各经络头痛VAS评分均明显低于本组治疗后0.5 h,治疗组治疗后2 h太阳头痛VAS评分较对照组明显升高(P<0.05或P<0.01)。治疗组75例患者头痛缓解,对照组83例患者头痛缓解。除太阳头痛外,其余经络及总体头痛治疗组起效时间均短于对照组(P<0.05)。头痛缓解患者24 h内复发率治疗组(34.67%)与对照组(30.12%)比较差异无统计学意义(P>0.05)。两组均未见明显不良反应。结论 经络辨证塞鼻法可显著缓解偏头痛急性发作时的头痛程度和伴随症状,且起效较快,安全性好。Objective To explore immediate analgesic effect and safety of nasal plugging method based on channel pattern differentiation in treatment of acute migraine attack.Metheds Totally 186 migraine patients were randomly divided into treatment group and control group with 93 cases in each group,and then classified into four types of headache including Jueyin(厥阴),Shaoyang(少阳),Taiyang(太阳)and Yangming(阳明)headache based on the channel pattern differentiation.The treatment group was given 0.2 g of corresponding nasal plugging powder based on the channel pattern in to the external nasal passage for 15 minutes,while the control group was given 0.3 g of ibuprofen sustained-release capsule orally.Both groups were given medication once at the time of acute attack of headache.The visual analogue scale(VAS)score before treatment,0.5 and 2 hours after treatment,concomitant symptom scores before treatment,0.5 hours after treatment were compared between groups,as well as the taking-effect time of drugs after treatment and the recurrence rate within 24 hours in patients with headache relief.Results The 0.5 h-and 2 h-VAS scores after treatment at overall level and of different headache type,as well as the 0.5 h-concomitant symptom score after treatment at overall level and of Shaoyang,Taiyang and Yangming headache significantly decreased in both groups compared to those before treatment;the 2 h-VAS score at overall level and of all types of headache were significantly lower than 0.5 h-VAS scores after treatment in both groups;the 2 h-VAS score of Taiyang headache after treatment was significantly higher in the treatment group than in the control group(P<0.05 or P<0.01).Seventy-five patients in the treatment group and 83 patients in the control group had headache relief.Except for Taiyang headache,other pattern headache in the treatment group took effect faster than in the control group(P<0.05).There was no significant difference in recurrence rate within 24 hours between the treatment group(34.67%)and control group(30.1

关 键 词：偏头痛 急性发作 经络辨证 塞鼻法 即刻止痛 

分 类 号：R277.7[医药卫生—中医学]