Seroprevalence of viral and bacterial pathogens among malaria patients in an endemic area of southern Venezuela  

作　　者：David A.Forero-Peña Fhabián S.Carrión-Nessi Mary Lopez-Perez Marisol Sandoval-de Mora Iván D.Amaya Ángel F.Gamardo Melynar Chavero Luisamy Figuera María V.Marcano Natasha A.Camejo-Ávila Mariana Hidalgo Cariagne J.Arenas Myriam Arévalo-Herrera Sócrates Herrera 

机构地区：[1]不详

出　　处：《Infectious Diseases of Poverty》2023年第2期130-131,共2页贫困所致传染病（英文）

摘　　要：Background Malaria remains a leading public health problem worldwide.Co-infections with other pathogens complicate its diagnosis and may modify the disease’s clinical course and management.Similarities in malaria clinical presentation with other infections and overlapping endemicity result in underdiagnosis of co-infections and increased mortality.Thus,the aim of this study was to determine the seroprevalence of viral and bacterial pathogens among diagnosed malaria patients in malaria-endemic areas in Venezuela.Methods A cross-sectional study was conducted on malaria patients attending three reference medical centres in Ciudad Bolivar,Venezuela.Clinical evaluation and laboratory tests for dengue virus(DENV),chikungunya virus(CHIKV),viral hepatitis[hepatitis A virus(HAV),hepatitis B virus(HBV),and hepatitis C virus(HCV)],and leptospirosis(LEP)were performed by enzyme-linked immunosorbent assays.Previous exposure to these pathogens was defined by the presence of specific immunoglobulin(Ig)G,and co-infection or recent exposure(CoRE)was determined by the presence of specific IgM alone or IgM+IgG.Data analysis considered descriptive statistics.Parameter distribution was statistically evaluated using Kolmogorov–Smirnov test and the necessary comparison tests.Odds ratio(OR)for complications was determined according to CoRE presence with a 95%confidence interval(CI).Results A total of 161 malaria patients were studied,66%infected with Plasmodium vivax,27%with P.falciparum,and 7.5%harboured P.vivax/P.falciparum mixed infection.Previous exposure to DENV(60%)and CHIKV(25%)was frequent.CoRE was confirmed in 55 of the 161 malaria patients(34%)and were more frequent in P.falciparum(49%)than in P.vivax(29%)and mixed malaria patients(25%)(OR=2.43,95%CI:1.39–4.25,P=0.018).The most frequent CoRE was DENV(15%),followed by HAV(12%),HBV(6.2%),CHIKV(5.5%),and LEP(3.7%);HCV CoRE was absent.Complicated malaria was significantly more frequent in patients with CoRE(56%)than those without CoRE(36%;OR=2.31,95%CI:1.18–4.92,P=0.013).C

关 键 词：MALARIA SEROPREVALENCE CO-INFECTION CHIKUNGUNYA DENGUE Hepatitis VENEZUELA 

分 类 号：R531.3[医药卫生—内科学]