Localized delivery of nanomedicine and antibodies for combating COVID-19  

作　　者：Bin Tu Yanrong Gao Xinran An Huiyuan Wang Yongzhuo Huang 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]University of Michigan College of Pharmacy,Ann Arbor,MI 48109,USA [4]Zhongshan Institute for Drug Discovery,SIMM,CAS,Zhongshan 528437,China [5]NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,Shanghai 201203,China [6]Taizhou University,School of Advanced Study,Institute of Natural Medicine and Health Product,Taizhou 318000,China

出　　处：《Acta Pharmaceutica Sinica B》2023年第5期1828-1846,共19页药学学报（英文版）

基　　金：support of the National Key Research and Development Program of China 627(2021YFE0103100,China);National Nature Science Foundation of China(81925035);Shanghai Sci-Tech Innovation Initiative(19431903100 and 18430740800,China);the Sanofi-SIBS Yong Faculty Award(China);the Youth Innovation Promotion Association(China);granted as High-level New R&D Institute(2019B090904008);High-level Innovative Research Institute(2021B0909050003)by Department of Science and Technology of Guangdong Province,China。

摘　　要：The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has been a major health burden in the world.So far,many strategies have been investigated to control the spread of COVID-19,including social distancing,disinfection protocols,vaccines,and antiviral treatments.Despite the significant achievement,due to the constantly emerging new variants,COVID-19 is still a great challenge to the global healthcare system.It is an urgent demand for the development of new therapeutics and technologies for containing the wild spread of SARS-CoV-2.Inhaled administration is useful for the treatment of lung and respiratory diseases,and enables the drugs to reach the site of action directly with benefits of decreased dose,improved safety,and enhanced patient compliance.Nanotechnology has been extensively applied in the prevention and treatment of COVID-19.In this review,the inhaled nanomedicines and antibodies,as well as intranasal nanodrugs,for the prevention and treatment of COVID-19 are summarized.

关 键 词：SARS-CoV-2 COVID-19 NANOMEDICINE Orally-inhaled delivery Intranasal delivery ANTIBODY 

分 类 号：R943[医药卫生—药剂学]