Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders  

作　　者：Rania Awad Avi Avital Alejandro Sosnik 

机构地区：[1]Laboratory of Pharmaceutical Nanomaterials Science,Department of Materials Science and Engineering,Technion-Israel Institute of Technology,Haifa 3200003,Israel [2]Behavioral Neurobiology Laboratory,Department of Occupational Therapy,Faculty of Social Welfare and Health Sciences,University of Haifa,Haifa 3498838,Israel

出　　处：《Acta Pharmaceutica Sinica B》2023年第5期1866-1886,共21页药学学报（英文版）

基　　金：the NEVET Nanotechnology Grant of the Russell Berrie Nanotechnology Institute(RBNI)at Technion—Israel Institute of Technology(Israel);the Tamara and Harry Handelsman Academic Chair(Israel)for financial support。

摘　　要：Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system(CNS)and result in their damage and death.Neurodevelopmental disorders include intellectual disability,autism spectrum disorder,and attention-deficit/hyperactivity disorder and stem from the disruption of essential neurodevelopmental processes.The treatment of neurodegenerative and neurodevelopmental conditions,together affecting~120 million people worldwide,is challenged by the blood—brain barrier(BBB)and the blood—cerebrospinal fluid barrier that prevent the crossing of drugs from the systemic circulation into the CNS.The nose-to-brain pathway that bypasses the BBB and increases the brain bioavailability of intranasally administered drugs is promising to improve the treatment of CNS conditions.This pathway is more efficient for nanoparticles than for solutions,hence,the research on intranasal nano-drug delivery systems has grown exponentially over the last decade.Polymeric nanoparticles have become key players in the field owing to the high design and synthetic flexibility.This review describes the challenges faced for the treatment of neurodegenerative and neurodevelopmental conditions,the molecular and cellular features of the nasal mucosa and the contribution of intranasal nano-drug delivery to overcome them.Then,a comprehensive overview of polymeric nanocarriers investigated to increase drug bioavailability in the brain is introduced.

关 键 词：Neurodegenerative diseases Neurodevelopmental disorders Central nervous system Blood—brain barrier Nano-drug delivery systems Nose-to-brain pathway Intranasal administration Polymeric nanoparticles Polymeric micelles DENDRIMERS 

分 类 号：R943[医药卫生—药剂学]