抗IFN-γ自身抗体相关非结核分枝杆菌感染研究进展  

Research progress on non-tuberculous mycobacterial infection relevant to anti-IFN-γ autoantibodies

作　　者：杨亚敏(综述)[1] 李庭红(审校)[1] YANG Ya-min;LI Ting-hong(The Third Central Hospital of Tianjin,Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases,Artificial Cell Engineering Technology Research Center,Infection Management Office of Tianjin Institute of Hepatobiliary Diseases,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院天津市重症疾病体外生命支持重点实验室、天津市人工细胞工程技术研究中心、天津市肝胆疾病研究所感染管理处,天津300170

出　　处：《中国感染控制杂志》2023年第6期738-742,共5页Chinese Journal of Infection Control

摘　　要：抗IFN-γ自身抗体引起成人免疫缺陷,从而导致机会性致病菌感染,是最近出现的医学问题。非结核分枝杆菌(NTM)感染是抗IFN-γ自身抗体阳性患者最常见的感染,近年来抗IFN-γ自身抗体相关的NTM感染不断增多。本文就抗IFN-γ自身抗体相关NTM感染的致病机制、NTM物种、临床表现及免疫调节辅助治疗等方面作一综述,为临床医生进一步了解此病,避免误诊和漏诊,并在合理治疗等方面提供帮助。Anti-IFN-γautoantibodies cause adult immune deficiency,leading to opportunistic bacterial infection,which is a recent medical issue.Nontuberculous mycobacterial(NTM)infection is the most common infection in patients with positive anti-IFN-γautoantibodies,and NTM infection relevant to anti-IFN-γautoantibodies has been increasing in recent years.This article reviews the pathogenic mechanism,NTM species,clinical manifestations and immunoregulation adjuvant therapy of anti-IFN-γautoantibody-associated NTM infection,aiming to help clinicians better understand this disease,avoid misdiagnosis and missed diagnosis,as well as conduct rational treatment.

关 键 词：抗IFN-γ自身抗体 非结核分枝杆菌 非结核分枝杆菌感染 致病机制 物种 治疗 

分 类 号：R52[医药卫生—内科学]