细银质针导热疗法联合普瑞巴林治疗带状疱疹后遗神经痛的疗效及对炎性因子的影响  

Efficacy of Fine Silver Needle Heat Conduction Therapy Combined with Pregabalin in Treatment of PHN and Its Influence to Inflammatory Factors

作　　者：李非铭 舒雅[1] LI Feiming;SHU Ya(The First Affiliated Hospital of Xi'an Medical College,Xi'an 710077,China)

机构地区：[1]西安医学院第一附属医院,陕西西安710077

出　　处：《针灸临床杂志》2023年第5期26-30,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：陕西省重点研发计划项目,编号:2019SF-314。

摘　　要：目的:探讨细银质针导热疗法联合普瑞巴林治疗带状疱疹后遗神经痛(PNH)的疗效及对炎性因子的影响。方法:按随机数字表法将西安医学院第一附属医院2019年4月—2022年4月收治PNH患者119例分成对照组(59例)与治疗组(60例)。对照组给予普瑞巴林治疗,治疗组在对照组基础上联合细银质针导热疗法治疗。比较两组治疗前后中医症候积分、视觉模拟评分(VAS)、匹兹堡睡眠质量指数量表(PSQI)和生活质量指数(DLQI)、血清炎性因子[白细胞介素-2(IL-2)、IL-6及肿瘤坏死因子-α(TNF-α)]变化,分析其疗效和不良反应情况。结果:与对照组比较,治疗组总有效率[96.67%(58/60)]高于对照组[84.75%(50/59)],差异有统计学意义(P<0.05);治疗前治疗组与对照组中医症状积分比较,差异无统计学意义(P>0.05),治疗后治疗组与对照组中医症状积分均降低,且治疗组神疲乏力、头晕目眩、夜寐不安和焦虑狂躁评分均低于对照组,差异有统计学意义(P<0.01);治疗前治疗组与对照组VAS、PSQI和DLQI评分比较,差异无统计学意义(P>0.05),治疗后治疗组与对照组VAS、PSQI和DLQI评分均降低,且治疗组治疗后VAS、PSQI和DLQI评分均低于对照组(P<0.01);治疗前治疗组与对照组炎性因子指标比较,差异无统计学意义(P>0.05),治疗后治疗组与对照组炎性因子水平降低,且治疗组IL-2、IL-6及TNF-α水平均低于对照组(P<0.01);不良反应对照组[8.47%(3/59)]与治疗组[3.33%(1/60)]比较差异无统计学意义(P>0.05)。结论:细银质针导热疗法联合普瑞巴林治疗PNH患者疗效理想,可改善其症状,降低疼痛和炎症反应,提高患者睡眠质量与生活质量,具有安全性。Objective:To explore the effect of silver needle heat conduction therapy combined with Pregabalin on postherpetic neuralgia(PHN)and its influence to inflammatory factors.Methods:119 PHN cases were randomly divided into the control group(n=59)and the treatment group(n=60).The control group was treated with Pregabalin;on which basis,the treatment group was also treated with fine silver needle heat conduction therapy.Scores of TCM symptoms,visual analogue scale(VAS)and Pittsburgh Sleep Quality Index(PSQI),daily life quality index(DLQI),as well as serum inflammatory factors of IL-2,IL-6 and TNF-ɑwere compared between before and after the treatment in the two groups.Clinical efficacy and adverse reactions were also compared between the two groups.Results:The total effective rate of the treatment group was[96.67%(58/60)],which was significantly higher than[84.75%(50/59)](P<0.05).There was no statistical difference in TCM symptomatic scores between the two groups before the treatment(P>0.05);the scores of TCM symptoms were all decreased after the treatment compared with those before the treatment in the two groups(P<0.05),and the scores of fatigue,dizziness,disrupted sleep,as well as anxiety and mania were lower in the treatment group than those in the control group after the treatment(P<0.05).There were no statistical differences in the scores of VAS,PSQI and DLQI between the two groups before the treatment(P>0.05);the scores were all decreased after the treatment in the two groups(P<0.05),and the decreases in the treatment group were more significant than those in the control group(P<0.05).There were no statistical differences in the indexes of the inflammatory factors between the two groups before the treatment(P>0.05);the inflammatory factors were all decreased after the treatment in the two groups after the treatment(P<0.05),and the levels of IL-2,IL-6 and TNF-α in the treatment group were lower than those in the control group after the treatment(P<0.05).The adverse reactions rate was[8.47%(3/59)]in the control g

关 键 词：细银质针导热 普瑞巴林 带状疱疹 后遗神经痛 炎性因子 

分 类 号：R246.7[医药卫生—针灸推拿学]