针刺抗炎的神经生物学机制研究进展  

Research Progress on Neurobiological Mechanism of Acupuncture in Anti-Inflammation

作　　者：杨霖 周丹[1] 陈波[1] 曹娇娇 郭义[1] 林小伟 YANG Lin;ZHOU Dan;CHEN Bo;CAO Jiaojiao;GUO Yi;LIN Xiaowei(Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学实验针灸学研究中心,天津301617

出　　处：《针灸临床杂志》2023年第5期108-112,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：国家自然科学基金重点项目,编号:82030125;国家自然科学基金青年项目,编号:82105024;天津市科技计划项目,编号:20JCQNJC00280;天津市卫生健康委员会青年项目,编号:2021056。

摘　　要：针刺抗炎疗效显著,在国内外应用广泛。自主神经系统介导的针刺抗炎作用机制已经在不同疾病模型中得到广泛验证,而最近新的研究报道深化了针刺抗炎的神经生物学机制。笔者结合最近针刺抗炎的神经生物学机制的新发现,系统总结了针刺介导的以副交感神经系统为主的胆碱能抗炎途径、迷走神经-肾上腺髓质-多巴胺通路和交感神经抗炎途径的机制研究进展。即副交感神经和交感神经系统在大脑皮质及下丘脑的支配下,既拮抗又协调地调节器官的生理活动。而针刺介导的自主神经抗炎作用与机体状态、电针强度有密切关系,具有双向良性调节的特点。本研究系统梳理针刺抗炎的神经生物学机制进展,以期为针刺抗炎的基础研究和临床应用提供思路。Acupuncture has an obvious anti-inflammatory effect and is widely used at home and abroad.The mechanism of acupuncture in anti-inflammation mediated by autonomic nervous system has been widely verified in different disease models,and recent research reports have deepened the neurobiological mechanism of acupuncture in anti-inflammation.In combination with the recent discovery of the neurobiological mechanism of acupuncture in anti-inflammation,this study systematically summarized the research progress of the mechanism of acupuncture mediated cholinergic anti-inflammatory pathway mainly involving parasympathetic nervous system,vagus adrenal medulla dopamine pathway and sympathetic anti-inflammatory pathway.Parasympathetic nerve and sympathetic nervous system,under the control of cerebral cortex and hypothalamus,both antagonize and coordinate the physiological activities of organs.The anti-inflammatory effect of autonomic nerve mediated by acupuncture is closely related to the state of the body and the intensity of electro-acupuncture,and has the characteristics of bi-directional benign regulation.This study systematically reviewed the progress of neurobiological mechanism of acupuncture in anti-inflammation,with a view to providing ideas for the basic research and clinical application of acupuncture in anti-inflammation.

关 键 词：针刺 抗炎 自主神经 交感神经 副交感神经 机制研究 

分 类 号：R245[医药卫生—针灸推拿学]