一种低温型季铵盐消毒剂的性能研究  

Study on the Performance of a Low Temperature Quaternary Ammonium Salt Disinfectant

作　　者：倪志华 林秋明 Ni Zhihua;Lin Qiuming(Fujian Vocational College of Bioengeering,Fuzhou 350002,China;Fuzhou Yuanquan Biological Technology Co.,Ltd.,Fuzhou 350109,China)

机构地区：[1]福建生物工程职业技术学院,福建福州350002 [2]福州源泉生物科技有限公司,福建福州350109

出　　处：《山东化工》2023年第7期27-29,共3页Shandong Chemical Industry

基　　金：2021年福建省科技特派员项目;2021年福州市科技特派员项目;2022年福州市高新区科技特派员项目。

摘　　要：目的:观察一种以复合季铵盐为有效成分的低温型消毒剂的杀菌性能、稳定性及安全性。方法:进行低温载体浸泡定量杀菌试验、理化实验与毒理学试验。结果:-20℃下,原液浸泡作用15 min,对载体上的金黄色葡萄球菌、大肠杆菌的杀灭对数均大于3.00;37℃,放置90 d后,复合季铵盐(以苯扎氯铵计)的下降率为6.2%;在-20℃下放置10 h后,消毒剂保持液体、无析出、无结晶;小鼠LD50均大于5000 mg/kg BW;微核试验结果为阴性;对日本大耳白种家兔一次完整皮肤刺激试验结果为无刺激性。结论:该低温型季铵盐消毒剂具有良好的杀菌性能、稳定性及安全性。Objective:To observe the germicidal efficacy,stability and safety of a low temperature disinfectant with compound quaternary ammonium salt as an effective component.Methods:The quantitative germicidal test,physical and chemical test and toxicological test were carried out by low temperature carrier immersion.Results:At-20℃,the logarithms of killing escherichia coli and staphylococcus aureus on the carrier were greater than 3.00 when the original solution was soaked for 15 minutes.At 37℃,after being placed for 90 days,the decrease rate of compound quaternary ammonium salt(calculated by benzalkonium chloride)was 6.2%.After being placed at-20℃for 10 h,the disinfectant will remain liquid without precipitation and crystallization.The oral LD50 of mice was more than 5000 mg/kg BW.The micronucleus test of polychromatic erythrocytes in mouse bone marrow was negative.A complete skin irritation test on Japanese white rabbits with big ears showed no irritation.Conclusion:The low temperature quaternary ammonium salt disinfectant has good bactericidal performance,stability and safety.

关 键 词：季铵盐 低温消毒剂 杀菌性能 稳定性 安全性 

分 类 号：TQ455.4[化学工程—农药化工]