银屑病与代谢合并症的遗传关系研究进展  

Advances in the study of genetic links between psoriasis and metabolic comorbidity

作　　者：吉晓娟 陈华清 赖忆玲 叶小英[2,3] 曾招林 万春雷[2,3] 李龙年 JI Xiao-juan;CHEN Hua-qing;LAI Yi-ling;YE Xiao-ying;ZENG Zhao-lin;WAN Chun-lei;LI Long-nian(The First Clinical Medical School of Gannan Medical University;Department of Dermatology,The First Affiliated Hospital of Gannan Medical University;Construction Unit of Branch Center of National Clinical Research Center for Dermatologic and Immunological Diseases,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院第一临床医学院 [2]赣南医学院第一附属医院皮肤科 [3]国家皮肤与免疫疾病临床医学研究中心分中心,江西赣州341000

出　　处：《赣南医学院学报》2023年第4期424-428,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江西省教育厅科学技术研究项目(GJJ170887);赣州市指导性科技计划项目(GZ2018ZSF093)。

摘　　要：银屑病是一种常见的炎症性皮肤病,由多种遗传和环境危险因素相互作用引起。与一般人群相比,银屑病患者高血压、胰岛素抵抗和2型糖尿病、血脂异常、肥胖的患病率更高。银屑病代谢合并症影响疾病严重程度,降低患者生活质量,甚至缩短患者预期寿命。研究表明,银屑病和许多代谢性疾病存在共同的遗传因素。本文综述并探讨高血压、肥胖、血脂异常、糖尿病与银屑病在遗传方面的关系,分析银屑病与这4种慢性代谢性疾病的共同遗传基础,为银屑病和代谢合并症的防治和银屑病管理的改善提供依据。Psoriasis is a common inflammatory skin disease caused by the interaction of multiple genetic and environmental risk factors.Patients with psoriasis have a higher prevalence of hypertension,insulin resistance and type 2 diabetes,dyslipidaemia and obesity compared to the general population.The metabolic comorbidity of psoriasis affects the severity of the disease,reduces the quality of life of patients and even leads to a shorter life expectancy.Studies have shown that psoriasis and many metabolic disorders share a common genetic component.This paper reviews and examines the genetic links between hypertension,obesity,dyslipidaemia,diabetes and psoriasis,and analyses the common genetic basis of psoriasis and these four chronic metabolic diseases,in order to provide a basis for the prevention and treatment of psoriasis and metabolic comorbidity and to improve the management of psoriasis.

关 键 词：银屑病 慢性代谢性疾病 代谢合并症 遗传关系 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]